Trim66 tripartite motif-containing 66 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim66provided by MGI
Official Full Name: tripartite motif-containing 66provided by MGI
Primary source: MGI:MGI:2152406
See related: Ensembl:ENSMUSG00000031026 AllianceGenome:MGI:2152406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tif1d; Kiaa0298-hp
Summary: Enables chromatin binding activity and identical protein binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in chromocenter and nucleus. Is expressed in olfactory epithelium. Orthologous to human TRIM66 (tripartite motif containing 66). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 5.6), cortex adult (RPKM 3.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 57.21 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (109048208..109115948, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (109449001..109516759, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trim66's paternal deficiency causes intrauterine overgrowth.
Title: Trim66's paternal deficiency causes intrauterine overgrowth.
Data suggest a role for transcriptional intermediary factor 1 (TIF1) delta in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis.
Title: TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mill8 (e-PCR), detects polymorphism
- UniSTS:142684

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing protein 66

Names: TIF1delta; transcriptional intermediary factor 1 delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170912.1 → NP_001164383.1 tripartite motif-containing protein 66 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC124457

Consensus CDS

CCDS52360.1

UniProtKB/Swiss-Prot

E9QLR8, Q5SEK4, Q5SEK5, Q924W6

UniProtKB/TrEMBL

B2RQQ4

Related

ENSMUSP00000102352.3, ENSMUST00000106741.10

Conserved Domains (4) summary

cd05502
Location:1170 → 1278

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:210 → 335

BBC; B-Box C-terminal domain

pfam00643
Location:166 → 201

zf-B_box; B-box zinc finger

cl22851
Location:1097 → 1145

PHD_SF; PHD finger superfamily
NM_001170913.1 → NP_001164384.1 tripartite motif-containing protein 66 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC124457, AK147559

Consensus CDS

CCDS52359.1

UniProtKB/TrEMBL

E9PZP2, Q3UH62

Related

ENSMUSP00000102350.2, ENSMUST00000106739.8

Conserved Domains (4) summary

cd05502
Location:1068 → 1176

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:108 → 233

BBC; B-Box C-terminal domain

pfam00643
Location:64 → 99

zf-B_box; B-box zinc finger

cl22851
Location:995 → 1043

PHD_SF; PHD finger superfamily
NM_181853.4 → NP_862901.3 tripartite motif-containing protein 66 isoform 2

See identical proteins and their annotated locations for NP_862901.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC124457

Consensus CDS

CCDS40082.1

UniProtKB/TrEMBL

B2RQQ4

Related

ENSMUSP00000033339.7, ENSMUST00000033339.8

Conserved Domains (8) summary

cd05502
Location:1068 → 1176

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:108 → 233

BBC; B-Box C-terminal domain

PHA03369
Location:379 → 614

PHA03369; capsid maturational protease; Provisional

pfam05109
Location:548 → 782

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09770
Location:293 → 449

PAT1; Topoisomerase II-associated protein PAT1

cd19794
Location:63 → 105

Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cd19811
Location:4 → 40

Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cl22851
Location:995 → 1043

PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

109048208..109115948 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507959.2 → XP_006508022.1 tripartite motif-containing protein 66 isoform X1

See identical proteins and their annotated locations for XP_006508022.1

UniProtKB/TrEMBL

B2RQQ4

Conserved Domains (8) summary

cd05502
Location:1068 → 1176

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:108 → 233

BBC; B-Box C-terminal domain

PHA03369
Location:379 → 614

PHA03369; capsid maturational protease; Provisional

pfam05109
Location:548 → 782

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09770
Location:293 → 449

PAT1; Topoisomerase II-associated protein PAT1

cd19794
Location:63 → 105

Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cd19811
Location:4 → 40

Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cl22851
Location:995 → 1043

PHD_SF; PHD finger superfamily
XM_036153179.1 → XP_036009072.1 tripartite motif-containing protein 66 isoform X2

UniProtKB/TrEMBL

B2RQQ4

Conserved Domains (5) summary

cd05502
Location:979 → 1087

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:19 → 144

BBC; B-Box C-terminal domain

PHA03369
Location:293 → 525

PHA03369; capsid maturational protease; Provisional

PRK12757
Location:419 → 510

PRK12757; cell division protein FtsN; Provisional

cd15625
Location:906 → 954

PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)
XM_006507961.5 → XP_006508024.1 tripartite motif-containing protein 66 isoform X1

See identical proteins and their annotated locations for XP_006508024.1

UniProtKB/TrEMBL

B2RQQ4

Conserved Domains (8) summary

cd05502
Location:1068 → 1176

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:108 → 233

BBC; B-Box C-terminal domain

PHA03369
Location:379 → 614

PHA03369; capsid maturational protease; Provisional

pfam05109
Location:548 → 782

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09770
Location:293 → 449

PAT1; Topoisomerase II-associated protein PAT1

cd19794
Location:63 → 105

Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cd19811
Location:4 → 40

Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cl22851
Location:995 → 1043

PHD_SF; PHD finger superfamily
XM_011241835.4 → XP_011240137.1 tripartite motif-containing protein 66 isoform X1

See identical proteins and their annotated locations for XP_011240137.1

UniProtKB/TrEMBL

B2RQQ4

Conserved Domains (8) summary

cd05502
Location:1068 → 1176

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:108 → 233

BBC; B-Box C-terminal domain

PHA03369
Location:379 → 614

PHA03369; capsid maturational protease; Provisional

pfam05109
Location:548 → 782

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09770
Location:293 → 449

PAT1; Topoisomerase II-associated protein PAT1

cd19794
Location:63 → 105

Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cd19811
Location:4 → 40

Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cl22851
Location:995 → 1043

PHD_SF; PHD finger superfamily
XM_006507960.4 → XP_006508023.1 tripartite motif-containing protein 66 isoform X1

See identical proteins and their annotated locations for XP_006508023.1

UniProtKB/TrEMBL

B2RQQ4

Conserved Domains (8) summary

cd05502
Location:1068 → 1176

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:108 → 233

BBC; B-Box C-terminal domain

PHA03369
Location:379 → 614

PHA03369; capsid maturational protease; Provisional

pfam05109
Location:548 → 782

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09770
Location:293 → 449

PAT1; Topoisomerase II-associated protein PAT1

cd19794
Location:63 → 105

Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cd19811
Location:4 → 40

Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cl22851
Location:995 → 1043

PHD_SF; PHD finger superfamily
XM_006507962.2 → XP_006508025.1 tripartite motif-containing protein 66 isoform X1

See identical proteins and their annotated locations for XP_006508025.1

UniProtKB/TrEMBL

B2RQQ4

Conserved Domains (8) summary

cd05502
Location:1068 → 1176

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:108 → 233

BBC; B-Box C-terminal domain

PHA03369
Location:379 → 614

PHA03369; capsid maturational protease; Provisional

pfam05109
Location:548 → 782

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09770
Location:293 → 449

PAT1; Topoisomerase II-associated protein PAT1

cd19794
Location:63 → 105

Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cd19811
Location:4 → 40

Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cl22851
Location:995 → 1043

PHD_SF; PHD finger superfamily
XM_036153180.1 → XP_036009073.1 tripartite motif-containing protein 66 isoform X3

Conserved Domains (4) summary

smart00502
Location:108 → 233

BBC; B-Box C-terminal domain

PHA03369
Location:379 → 614

PHA03369; capsid maturational protease; Provisional

cd19794
Location:63 → 105

Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins

cd19811
Location:4 → 40

Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins