Dus2 dihydrouridine synthase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dus2provided by MGI
Official Full Name: dihydrouridine synthase 2provided by MGI
Primary source: MGI:MGI:1913619
See related: Ensembl:ENSMUSG00000031901 AllianceGenome:MGI:1913619
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dus2l; 2310016K04Rik
Summary: Predicted to enable several functions, including double-stranded RNA binding activity; nucleotide binding activity; and tRNA-dihydrouridine20 synthase activity. Predicted to be involved in antiviral innate immune response and tRNA dihydrouridine synthesis. Located in mitochondrion. Is expressed in central nervous system and sensory organ. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 5.7), cerebellum adult (RPKM 5.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.07 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106738110..106780472)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (106011478..106053840)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Markers

Dus2l (e-PCR), detects polymorphism
- UniSTS:478996

AI449652 (e-PCR)
- UniSTS:164386

NoName (e-PCR)
- UniSTS:492371

NoName (e-PCR)
- UniSTS:224685

NoName (e-PCR)
- UniSTS:235988

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FMN binding	ISO Inferred from Sequence Orthology more info
enables FMN binding	ISS Inferred from Sequence or Structural Similarity more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA dihydrouridine synthase activity	ISO Inferred from Sequence Orthology more info
enables tRNA dihydrouridine synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA-dihydrouridine20 synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA dihydrouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA dihydrouridine synthesis	ISO Inferred from Sequence Orthology more info
involved_in tRNA dihydrouridine synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

NP_001288105.1

EC 1.3.1.91

NP_079794.1

EC 1.3.1.91

XP_006531341.1

EC 1.3.1.91

XP_030099573.1

EC 1.3.1.91

XP_030099575.1

EC 1.3.1.91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301176.1 → NP_001288105.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2

See identical proteins and their annotated locations for NP_001288105.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon and uses a downstream translation start codon compared to isoform 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK009391, AK077451, BB596733

UniProtKB/Swiss-Prot

Q9D7B1

Conserved Domains (2) summary

cd02801
Location:1 → 139

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

cd19871
Location:256 → 323

DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
NM_025518.4 → NP_079794.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

See identical proteins and their annotated locations for NP_079794.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK009391, AK077451, BB596733

Consensus CDS

CCDS22627.1

UniProtKB/Swiss-Prot

Q6PDX2, Q9D7B1

UniProtKB/TrEMBL

Q14A90

Related

ENSMUSP00000034375.5, ENSMUST00000034375.11

Conserved Domains (2) summary

cd02801
Location:13 → 252

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

cd19871
Location:369 → 436

DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

106738110..106780472

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243713.1 → XP_030099573.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X2

Conserved Domains (2) summary

cd02801
Location:75 → 223

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

cd19871
Location:340 → 407

DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
XM_030243715.1 → XP_030099575.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3

Conserved Domains (2) summary

cd02801
Location:1 → 139

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

cd19871
Location:256 → 323

DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
XM_006531278.3 → XP_006531341.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

See identical proteins and their annotated locations for XP_006531341.1

UniProtKB/Swiss-Prot

Q6PDX2, Q9D7B1

UniProtKB/TrEMBL

Q14A90

Conserved Domains (2) summary

cd02801
Location:13 → 252

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

cd19871
Location:369 → 436

DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins