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    Yjefn3 YjeF N-terminal domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 234365, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Yjefn3provided by MGI
    Official Full Name
    YjeF N-terminal domain containing 3provided by MGI
    Primary source
    MGI:MGI:2681845
    See related
    Ensembl:ENSMUSG00000048967 AllianceGenome:MGI:2681845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm175; YjeF_N3; hYjeF_N3
    Summary
    Predicted to enable NAD(P)HX epimerase activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; membrane raft distribution; and negative regulation of angiogenesis. Is expressed in dentate gyrus subgranular zone. Orthologous to human YJEFN3 (YjeF N-terminal domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Yjefn3 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.02 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70340438..70346633, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69887788..69893983, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2867 Neighboring gene STARR-seq mESC enhancer starr_21749 Neighboring gene pre B cell leukemia homeobox 4 Neighboring gene predicted gene, 33746 Neighboring gene cartilage intermediate layer protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E10503 Neighboring gene STARR-positive B cell enhancer ABC_E1757 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene testis-specific serine kinase 6 Neighboring gene GATA zinc finger domain containing 2A Neighboring gene STARR-positive B cell enhancer ABC_E5012 Neighboring gene STARR-positive B cell enhancer ABC_E1367 Neighboring gene STARR-seq mESC enhancer starr_21753 Neighboring gene STARR-seq mESC enhancer starr_21758 Neighboring gene STARR-positive B cell enhancer ABC_E89

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. Rudolph C, et al. Horm Metab Res, 2007 May. PMID 17533573
    2. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD(P)HX epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in hematopoietic stem cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane raft distribution ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    yjeF N-terminal domain-containing protein 3
    Names
    apoA-I-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353930.2 → NP_001340859.1  yjeF N-terminal domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AC158564
      Consensus CDS
      CCDS90407.1
      UniProtKB/Swiss-Prot
      F6W8I0, J3QM68, Q8R2K0
      Related
      ENSMUSP00000118931.3, ENSMUST00000152938.9
      Conserved Domains (1) summary
      cl25685
      Location:15 → 248
      PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70340438..70346633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F6W8I0.2 GenPept UniProtKB/Swiss-Prot:F6W8I0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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