Slc6a15 solute carrier family 6 (neurotransmitter transporter), member 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc6a15provided by MGI
Official Full Name: solute carrier family 6 (neurotransmitter transporter), member 15provided by MGI
Primary source: MGI:MGI:2143484
See related: Ensembl:ENSMUSG00000019894 AllianceGenome:MGI:2143484
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: v7-3
Summary: Enables branched-chain amino acid:sodium symporter activity; neutral L-amino acid:sodium symporter activity; and proline:sodium symporter activity. Involved in L-leucine transport and proline transport. Located in membrane. Is expressed in alimentary system; central nervous system; dorsal root ganglion; metanephros; and sensory organ. Orthologous to human SLC6A15 (solute carrier family 6 member 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 15.2), cerebellum adult (RPKM 9.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 53.98 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (103203320..103255240)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (103367808..103419379)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons.
Title: Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons.
Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility. The reduction of Slc6a15 occurs selectively in the NAc D2-neurons. Genetic reduction of Slc6a15 induces susceptibility to a subthreshold stress, while genetic overexpression in D2-neurons prevents social avoidance after chronic social defeat stress.
Title: Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress Susceptibility.
Slc6a15 plays a role in modulating emotional behavior, possibly mediated by its impact on glutamatergic neurotransmission.
Title: SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system.
SLC6A15 regulates the activity of the brain glutamatergic system through the proline-glutamate biosynthesis pathway, affecting hippocampal neurochemistry and consequently behavior.
Title: The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior.
Slc6a15 knockout mice demonstrate only modest alterations in rotarod performance with aging and lack reproducible alterations in other motor, memory, anxiety or olfactory tests
Title: Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors.
The structure and function of B0AT2 are reported.
Title: The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

AI326450 (e-PCR)
- UniSTS:160023

RH124494 (e-PCR)
- UniSTS:161316

Slc6a15 (e-PCR), detects polymorphism
- UniSTS:547131

NoName (e-PCR)
- UniSTS:236453

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables branched-chain amino acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables branched-chain amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables proline:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-leucine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in carboxylic acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in proline transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium-dependent neutral amino acid transporter B(0)AT2

Names: B0AT2 protein; orphan sodium- and chloride-dependent neurotransmitter transporter NTT73; orphan transporter v7-3; solute carrier family 6 member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252330.1 → NP_001239259.1 sodium-dependent neutral amino acid transporter B(0)AT2

See identical proteins and their annotated locations for NP_001239259.1

Status: VALIDATED

Description

Transcript Variant: This variant (b) differs in the 5' UTR, compared to variant c. Variants a, b and c encode the same protein.

Source sequence(s)

AW124505, BC076593

Consensus CDS

CCDS24156.1

UniProtKB/Swiss-Prot

Q333Y0, Q8BG16

Related

ENSMUSP00000136676.2, ENSMUST00000179636.3

Conserved Domains (1) summary

cd11522
Location:61 → 640

SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain
NM_001358821.1 → NP_001345750.1 sodium-dependent neutral amino acid transporter B(0)AT2

Status: VALIDATED

Description

Transcript Variant: This variant (c) represents the longest transcript. Variants a, b and c encode the same protein.

Source sequence(s)

AW124505, BC076593, CF736974, CN460271

Consensus CDS

CCDS24156.1

UniProtKB/Swiss-Prot

Q333Y0, Q8BG16

Conserved Domains (1) summary

cd11522
Location:61 → 640

SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain
NM_175328.3 → NP_780537.1 sodium-dependent neutral amino acid transporter B(0)AT2

See identical proteins and their annotated locations for NP_780537.1

Status: VALIDATED

Description

Transcript Variant: This variant (a) differs in the 5' UTR, compared to variant c. Variants a, b and c encode the same protein.

Source sequence(s)

AW124505, AY149280, BC076593

Consensus CDS

CCDS24156.1

UniProtKB/Swiss-Prot

Q333Y0, Q8BG16

Related

ENSMUSP00000073829.5, ENSMUST00000074204.12

Conserved Domains (1) summary

cd11522
Location:61 → 640

SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

103203320..103255240

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155449.1 → XP_036011342.1 sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

UniProtKB/Swiss-Prot

Q333Y0, Q8BG16

Conserved Domains (1) summary

cd11522
Location:61 → 640

SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain
XM_006512983.5 → XP_006513046.1 sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

See identical proteins and their annotated locations for XP_006513046.1

UniProtKB/Swiss-Prot

Q333Y0, Q8BG16

Conserved Domains (1) summary

cd11522
Location:61 → 640

SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain
XM_006512984.5 → XP_006513047.1 sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

See identical proteins and their annotated locations for XP_006513047.1

UniProtKB/Swiss-Prot

Q333Y0, Q8BG16

Conserved Domains (1) summary

cd11522
Location:61 → 640

SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain