Rab25 RAB25, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab25provided by MGI
Official Full Name: RAB25, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1858203
See related: Ensembl:ENSMUSG00000008601 AllianceGenome:MGI:1858203
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable GTP binding activity; GTPase activity; and myosin V binding activity. Involved in epithelial cell morphogenesis. Predicted to be located in cytoplasmic vesicle; plasma membrane; and pseudopodium. Predicted to be active in Golgi apparatus and recycling endosome. Is expressed in gut; nasal cavity epithelium; skin; submandibular gland primordium; and urinary system. Orthologous to human RAB25 (RAB25, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 161.0), stomach adult (RPKM 130.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.87 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88449335..88455586, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88542029..88548279, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency in the Rab25 gene leads to a decline in male fertility and testicular injury: Impact on the regulation of germ cell proliferation and apoptosis.
Title: Deficiency in the Rab25 gene leads to a decline in male fertility and testicular injury: Impact on the regulation of germ cell proliferation and apoptosis.
Rab25 is involved in hypospadias via the beta1 integrin/EGFR pathway.
Title: Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway.
A small Rho GTPase RAB25 with a potential role in chemotherapy resistance in pancreatic cancer.
Title: A small Rho GTPase RAB25 with a potential role in chemotherapy resistance in pancreatic cancer.
Loss of Rab25 promotes the development and neoplastic transition of skin squamous cell carcinoma through dysregulation of integrin trafficking.
Title: Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking.
Our results strongly confirm the tumorigenic role of Rab25 in tobacco carcinogen-induced lung cancer and demonstrate aerosol delivery of shRab25 as a therapeutic target for lung cancer treatment
Title: Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice.
Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cells.
Title: Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell.
a Grhl2/Ovol2 network controls Cldn4 and Rab25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
Title: A Grainyhead-Like 2/Ovo-Like 2 Pathway Regulates Renal Epithelial Barrier Function and Lumen Expansion.
tight regulation of CCN3 expression is necessary for normal cortical neuronal connectivity during development, and RAB25 negatively regulates neuronal differentiation as a downstream effector of CCN3
Title: CCN3 overexpression inhibits growth of callosal projections via upregulation of RAB25.
the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 and Cldn4, as well as of Rab25, which increases the Cldn4 protein and its localization at TJs
Title: Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25.
Rab25 may function as a tumor suppressor in intestinal epithelial cells through regulation of protein trafficking to the cell surface.
Title: Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables myosin V binding	IEA Inferred from Electronic Annotation more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in pseudopodium organization	ISO Inferred from Sequence Orthology more info
involved_in pseudopodium organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in pseudopodium membrane	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016899.4 → NP_058595.2 ras-related protein Rab-25

Status: PROVISIONAL

Source sequence(s)

AC145168

Consensus CDS

CCDS17477.1

UniProtKB/Swiss-Prot

Q9D1P3, Q9WTL2

UniProtKB/TrEMBL

Q0PD30

Related

ENSMUSP00000008745.7, ENSMUST00000008745.13

Conserved Domains (2) summary

PLN03110
Location:1 → 212

PLN03110; Rab GTPase; Provisional

cd01868
Location:11 → 174

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

88449335..88455586 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163162.1 → XP_036019055.1 ras-related protein Rab-25 isoform X1

UniProtKB/TrEMBL

D3YYB3

Related

ENSMUSP00000120505.2, ENSMUST00000131775.2

Conserved Domains (1) summary

cl38936
Location:7 → 120

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases