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    RPS29 ribosomal protein S29 [ Homo sapiens (human) ]

    Gene ID: 6235, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPS29provided by HGNC
    Official Full Name
    ribosomal protein S29provided by HGNC
    Primary source
    HGNC:HGNC:10419
    See related
    Ensembl:ENSG00000213741 MIM:603633; AllianceGenome:HGNC:10419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S29; uS14; DBA13
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in colon (RPKM 132.6), ovary (RPKM 125.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPS29 in Genome Data Viewer
    Location:
    14q21.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (49570988..49598710, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (43769235..43796961, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (50037706..50065428, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984701 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:50020527-50021112 Neighboring gene RNA, 5S ribosomal pseudogene 384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8309 Neighboring gene ribosomal protein L32 pseudogene 29 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:50049568-50050079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:50050080-50050590 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:50050591-50051102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8310 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:50053149-50053658 Neighboring gene RNA component of signal recognition particle 7SL1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8314 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:50065755-50066525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5696 Neighboring gene ras homolog family member Q pseudogene 1 Neighboring gene leucine rich repeat protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8317 Neighboring gene ribosomal protein L36a like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Diamond-Blackfan anemia 13
    MedGen: C4014641 OMIM: 615909 GeneReviews: Diamond-Blackfan Anemia
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    small ribosomal subunit protein uS14
    Names
    40S ribosomal protein S29

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050638.2 RefSeqGene

      Range
      17331..32723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1147

    mRNA and Protein(s)

    1. NM_001030001.4NP_001025172.1  small ribosomal subunit protein uS14 isoform 2

      See identical proteins and their annotated locations for NP_001025172.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) utilizes an alternate 3'-terminal exon, compared to variant 1, resulting in a longer isoform (2) with a unique C-terminus.
      Source sequence(s)
      AL139099, BC015974, BU942244
      Consensus CDS
      CCDS32072.1
      UniProtKB/Swiss-Prot
      P62273
      Related
      ENSP00000379339.3, ENST00000396020.7
      Conserved Domains (1) summary
      PTZ00218
      Location:154
      PTZ00218; 40S ribosomal protein S29; Provisional
    2. NM_001032.5NP_001023.1  small ribosomal subunit protein uS14 isoform 1

      See identical proteins and their annotated locations for NP_001023.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes isoform 1.
      Source sequence(s)
      BC035313, BU942244
      Consensus CDS
      CCDS9685.1
      UniProtKB/Swiss-Prot
      A8MZ73, P30054, P62273
      UniProtKB/TrEMBL
      A0A2R8Y6P7
      Related
      ENSP00000245458.7, ENST00000245458.11
      Conserved Domains (1) summary
      PTZ00218
      Location:156
      PTZ00218; 40S ribosomal protein S29; Provisional
    3. NM_001351375.2NP_001338304.1  small ribosomal subunit protein uS14 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate first exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL139099, HY027234
      Consensus CDS
      CCDS86388.1
      UniProtKB/TrEMBL
      A0A087WTT6
      Related
      ENSP00000478117.1, ENST00000557111.5
      Conserved Domains (1) summary
      cl00355
      Location:1953
      Ribosomal_S14; Ribosomal protein S14p/S29e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      49570988..49598710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      43769235..43796961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)