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    Serpinb7 serine (or cysteine) peptidase inhibitor, clade B, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 116872, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpinb7provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 7provided by MGI
    Primary source
    MGI:MGI:2151053
    See related
    Ensembl:ENSMUSG00000067001 AllianceGenome:MGI:2151053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    megsin; ovalbumin; 4631416M05Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity; positive regulation of biosynthetic process; and positive regulation of glomerular mesangial cell proliferation. Predicted to act upstream of or within regulation of proteolysis. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; Nagashima-type palmoplantar keratosis; and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINB7 (serpin family B member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Serpinb7 in Genome Data Viewer
    Location:
    1 E2.1; 1 50.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (107350418..107380419)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (107422689..107452689)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8089 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11 Neighboring gene STARR-positive B cell enhancer mm9_chr1:109342973-109343273 Neighboring gene STARR-positive B cell enhancer mm9_chr1:109343789-109344089 Neighboring gene predicted gene, 24553 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 2 Neighboring gene STARR-seq mESC enhancer starr_01868 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 Neighboring gene SCAN domain containing 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serpin B7
    Names
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7
    serine (or cysteine) proteinase inhibitor, clade B, member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027548.4NP_081824.1  serpin B7

      See identical proteins and their annotated locations for NP_081824.1

      Status: VALIDATED

      Source sequence(s)
      AC129295, AC148982
      Consensus CDS
      CCDS35686.1
      UniProtKB/Swiss-Prot
      Q9D695
      UniProtKB/TrEMBL
      Q6P3F8
      Related
      ENSMUSP00000083896.5, ENSMUST00000086690.6
      Conserved Domains (1) summary
      cl00137
      Location:4380
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      107350418..107380419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)