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    Serpinb8 serine (or cysteine) peptidase inhibitor, clade B, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 20725, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpinb8provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 8provided by MGI
    Primary source
    MGI:MGI:894657
    See related
    Ensembl:ENSMUSG00000026315 AllianceGenome:MGI:894657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAP2; NK10; Spi8; CAP-2; ovalbumin
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in epithelial cell-cell adhesion and negative regulation of endopeptidase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in peeling skin syndrome 5. Orthologous to human SERPINB8 (serpin family B member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 2.4), bladder adult (RPKM 2.0) and 16 other tissues See more
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    Genomic context

    See Serpinb8 in Genome Data Viewer
    Location:
    1 E2.1; 1 50.34 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (107517668..107536708)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (107589926..107608978)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 2 Neighboring gene STARR-seq mESC enhancer starr_01868 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01869 Neighboring gene STARR-seq mESC enhancer starr_01870 Neighboring gene predicted gene 15389 Neighboring gene STARR-seq mESC enhancer starr_01871 Neighboring gene predicted gene, 24267

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serpin B8
    Names
    serine (or cysteine) peptdiase inhibitor, clade B, member 8
    serine (or cysteine) proteinase inhibitor, clade B, member 8
    serine protease inhibitor 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159748.1NP_001153220.1  serpin B8 isoform 2

      See identical proteins and their annotated locations for NP_001153220.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK032659, AK048230
      UniProtKB/TrEMBL
      Q8C871
      Related
      ENSMUST00000151283.2
      Conserved Domains (1) summary
      cl38926
      Location:1241
      serpin; SERine Proteinase INhibitors (serpin) family
    2. NM_011459.4NP_035589.1  serpin B8 isoform 1

      See identical proteins and their annotated locations for NP_035589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC015658, AK032659, AK036811
      Consensus CDS
      CCDS15220.1
      UniProtKB/Swiss-Prot
      O08800
      UniProtKB/TrEMBL
      Q3UFM1
      Related
      ENSMUSP00000108326.3, ENSMUST00000112706.4
      Conserved Domains (1) summary
      cl00137
      Location:4374
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      107517668..107536708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529292.3XP_006529355.1  serpin B8 isoform X1

      See identical proteins and their annotated locations for XP_006529355.1

      UniProtKB/TrEMBL
      Q8C871
      Conserved Domains (1) summary
      cl38926
      Location:1241
      serpin; SERine Proteinase INhibitors (serpin) family