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    Dsel dermatan sulfate epimerase-like [ Mus musculus (house mouse) ]

    Gene ID: 319901, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dselprovided by MGI
    Official Full Name
    dermatan sulfate epimerase-likeprovided by MGI
    Primary source
    MGI:MGI:2442948
    See related
    Ensembl:ENSMUSG00000038702 AllianceGenome:MGI:2442948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DS-epi2; 9330132E09Rik
    Summary
    Enables chondroitin-glucuronate 5-epimerase activity. Acts upstream of or within chondroitin sulfate metabolic process and dermatan sulfate metabolic process. Predicted to be located in membrane. Is expressed in eye. Orthologous to human DSEL (dermatan sulfate epimerase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 4.2), bladder adult (RPKM 2.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dsel in Genome Data Viewer
    Location:
    1 E2.1; 1 50.84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (111786431..111792782, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (111858701..111865052, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921525D07 gene Neighboring gene STARR-seq mESC enhancer starr_01898 Neighboring gene STARR-seq mESC enhancer starr_01899 Neighboring gene STARR-seq mESC enhancer starr_01901 Neighboring gene STARR-seq mESC enhancer starr_01902 Neighboring gene STARR-seq mESC enhancer starr_01903 Neighboring gene STARR-seq mESC enhancer starr_01904 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01905 Neighboring gene ribosomal protein L9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01906 Neighboring gene STARR-seq mESC enhancer starr_01907 Neighboring gene CCR4-NOT transcription complex, subunit 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chondroitin-glucuronate 5-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chondroitin-glucuronate 5-epimerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chondroitin sulfate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within chondroitin sulfate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dermatan sulfate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within dermatan sulfate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dermatan-sulfate epimerase-like protein
    NP_001074785.1
    XP_017176672.1
    XP_030110808.1
    XP_036021587.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081316.2NP_001074785.1  dermatan-sulfate epimerase-like protein precursor

      See identical proteins and their annotated locations for NP_001074785.1

      Status: VALIDATED

      Source sequence(s)
      AC125403
      Consensus CDS
      CCDS35688.1
      UniProtKB/Swiss-Prot
      B2RQ79, Q0VBN2
      Related
      ENSMUSP00000043570.6, ENSMUST00000035462.7
      Conserved Domains (1) summary
      cl21551
      Location:10891146
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      111786431..111792782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254948.1XP_030110808.1  dermatan-sulfate epimerase-like protein isoform X1

      UniProtKB/Swiss-Prot
      B2RQ79, Q0VBN2
      Conserved Domains (1) summary
      cl21551
      Location:10891146
      Sulfotransfer_3; Sulfotransferase family
    2. XM_036165694.1XP_036021587.1  dermatan-sulfate epimerase-like protein isoform X1

      UniProtKB/Swiss-Prot
      B2RQ79, Q0VBN2
      Conserved Domains (1) summary
      cl21551
      Location:10891146
      Sulfotransfer_3; Sulfotransferase family
    3. XM_017321183.3XP_017176672.1  dermatan-sulfate epimerase-like protein isoform X1

      UniProtKB/Swiss-Prot
      B2RQ79, Q0VBN2
      Conserved Domains (1) summary
      cl21551
      Location:10891146
      Sulfotransfer_3; Sulfotransferase family