Stx7 syntaxin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx7provided by MGI
Official Full Name: syntaxin 7provided by MGI
Primary source: MGI:MGI:1858210
See related: Ensembl:ENSMUSG00000019998 AllianceGenome:MGI:1858210
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Syn7
Summary: Predicted to enable SNAP receptor activity; chloride channel inhibitor activity; and syntaxin binding activity. Involved in synaptic vesicle to endosome fusion. Located in endosome and perinuclear region of cytoplasm. Is active in synaptic vesicle membrane. Is expressed in central nervous system; embryonic visceral endoderm; ganglia; and neural retina. Orthologous to human STX7 (syntaxin 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 57.7), placenta adult (RPKM 42.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 11.45 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (24025182..24064859)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (24149289..24188961)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin 7 modulates seizure activity in epilepsy.
Title: Syntaxin 7 modulates seizure activity in epilepsy.
The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons.
Title: The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons.
Munc13-4 is a syntaxin 7 binding protein and an important regulator of late endosome maturation.
Title: Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses.
Colony-stimulating factor 1 is a key regulator of Stx7 expression and function in macrophages.
Title: Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI315064 (e-PCR)
- UniSTS:159962

RH136151 (e-PCR)
- UniSTS:210146

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info	PubMed
enables chloride channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in organelle localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle to endosome fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle to endosome fusion	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic vesicle to endosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in azurophil granule	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in tertiary granule	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358563.2 → NP_001345492.1 syntaxin-7

Status: VALIDATED

Source sequence(s)

AC125010

Consensus CDS

CCDS23749.1

UniProtKB/Swiss-Prot

O70439

UniProtKB/TrEMBL

Q8BH40

Related

ENSMUSP00000151638.2, ENSMUST00000220041.2

Conserved Domains (2) summary

cd00179
Location:13 → 150

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7
NM_001428950.1 → NP_001415879.1 syntaxin-7

Status: VALIDATED

Source sequence(s)

AC125010

UniProtKB/Swiss-Prot

O70439

UniProtKB/TrEMBL

Q8BH40
NM_016797.6 → NP_058077.2 syntaxin-7

See identical proteins and their annotated locations for NP_058077.2

Status: VALIDATED

Source sequence(s)

AC125010

Consensus CDS

CCDS23749.1

UniProtKB/Swiss-Prot

O70439

UniProtKB/TrEMBL

Q8BH40

Related

ENSMUSP00000020174.6, ENSMUST00000020174.7

Conserved Domains (2) summary

cd00179
Location:13 → 150

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

24025182..24064859

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512801.5 → XP_006512864.1 syntaxin-7 isoform X1

Conserved Domains (2) summary

cd00179
Location:13 → 150

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7