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    Kcnab3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 [ Mus musculus (house mouse) ]

    Gene ID: 16499, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnab3provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, beta member 3provided by MGI
    Primary source
    MGI:MGI:1336208
    See related
    Ensembl:ENSMUSG00000018470 AllianceGenome:MGI:1336208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kcnab4; mKv(beta)4; C330022D06Rik
    Summary
    Predicted to enable aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to be located in cytoplasm. Predicted to be part of voltage-gated potassium channel complex. Is expressed in central nervous system; eye; heart; intestine; and male reproductive gland or organ. Orthologous to human KCNAB3 (potassium voltage-gated channel subfamily A regulatory beta subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 22.4), frontal lobe adult (RPKM 21.7) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Kcnab3 in Genome Data Viewer
    Location:
    11 B3; 11 42.51 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69217084..69223867)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69326258..69333041)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene centrobin, centrosomal BRCA2 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E1829 Neighboring gene trafficking protein particle complex 1 Neighboring gene ring finger protein 227 Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene predicted gene, 22442

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    voltage-gated potassium channel subunit beta-3
    Names
    K(+) channel subunit beta-3
    kv-beta-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010599.4NP_034729.3  voltage-gated potassium channel subunit beta-3

      See identical proteins and their annotated locations for NP_034729.3

      Status: VALIDATED

      Source sequence(s)
      AK049316, AK083134
      Consensus CDS
      CCDS24890.1
      UniProtKB/TrEMBL
      Q8BQX9, Q8C439, Q8C7S9, Q8VD73
      Related
      ENSMUSP00000018614.3, ENSMUST00000018614.3
      Conserved Domains (2) summary
      cd06660
      Location:80395
      Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
      TIGR01293
      Location:80396
      Kv_beta; voltage-dependent potassium channel beta subunit, animal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69217084..69223867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)