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    Cfap144 cilia and flagella associated protein 144 [ Mus musculus (house mouse) ]

    Gene ID: 75429, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cfap144provided by MGI
    Official Full Name
    cilia and flagella associated protein 144provided by MGI
    Primary source
    MGI:MGI:1922679
    See related
    Ensembl:ENSMUSG00000049154 AllianceGenome:MGI:1922679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Theg6; Fam183b; 3100002J23Rik
    Summary
    Predicted to enable microtubule binding activity. Involved in flagellated sperm motility. Located in centrosome and ciliary basal body. Is active in axonemal B tubule inner sheath; ciliary base; and sperm flagellum. Is expressed in several structures, including brain ventricle and choroid plexus; gonad; notochord; respiratory system; and sensory organ. Orthologous to several human genes including CFAP144 (cilia and flagella associated protein 144). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 7.7), lung adult (RPKM 0.8) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Cfap144 in Genome Data Viewer
    Location:
    11 B1.3; 11 36.3 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58683628..58692786, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58783892..58802221, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily T member 45 Neighboring gene olfactory receptor family 2 subfamily T member 44 Neighboring gene olfactory receptor family 5 subfamily AC member 20 Neighboring gene olfactory receptor family 5 subfamily AF member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC143784

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal B tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ciliary base IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in ciliary base IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cilia- and flagella-associated protein 144
    Names
    family with sequence similarity 183, member B
    protein FAM183B
    testis highly expressed protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162878.3NP_001156350.2  cilia- and flagella-associated protein 144 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL662903
      Consensus CDS
      CCDS48807.2
      Related
      ENSMUSP00000051960.5, ENSMUST00000060581.5
      Conserved Domains (1) summary
      pfam14886
      Location:19101
      FAM183; FAM183A and FAM183B related
    2. NM_029283.3NP_083559.2  cilia- and flagella-associated protein 144 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL662903
      Consensus CDS
      CCDS48808.2
      UniProtKB/Swiss-Prot
      D2D553, Q3TZB7, Q5NC57, Q9CXW5
      Related
      ENSMUSP00000091708.6, ENSMUST00000094156.12
      Conserved Domains (1) summary
      pfam14886
      Location:19121
      FAM183; FAM183A and FAM183B related

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58683628..58692786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)