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    Alkal2 ALK and LTK ligand 2 [ Mus musculus (house mouse) ]

    Gene ID: 100294583, updated on 9-Dec-2024

    Summary

    Official Symbol
    Alkal2provided by MGI
    Official Full Name
    ALK and LTK ligand 2provided by MGI
    Primary source
    MGI:MGI:3697448
    See related
    Ensembl:ENSMUSG00000054204 AllianceGenome:MGI:3697448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam150b; Augalpha; 6230419C23Rik
    Summary
    Predicted to enable protein tyrosine kinase activator activity and signaling receptor binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of MAPK cascade; and positive regulation of neuron projection development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in brain. Orthologous to human ALKAL2 (ALK and LTK ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 1.2), limb E14.5 (RPKM 0.8) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Alkal2 in Genome Data Viewer
    Location:
    12 A2; 12 13.0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30934323..30943855)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30884324..30893856)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11506 Neighboring gene transmembrane protein 18 Neighboring gene STARR-seq mESC enhancer starr_31844 Neighboring gene predicted gene, 32320 Neighboring gene STARR-seq mESC enhancer starr_31845 Neighboring gene STARR-positive B cell enhancer ABC_E7128 Neighboring gene acid phosphatase 1, soluble Neighboring gene Sh3 domain YSC-like 1 Neighboring gene STARR-seq mESC enhancer starr_31846 Neighboring gene pyruvate kinase, muscle pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables receptor signaling protein tyrosine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor signaling protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor signaling protein tyrosine kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane receptor protein tyrosine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ALK and LTK ligand 2
    Names
    Augmentor alpha
    Protein FAM150B
    family with sequence similarity 150, member B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159743.2NP_001153215.1  ALK and LTK ligand 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001153215.1

      Status: VALIDATED

      Source sequence(s)
      AC160932
      Consensus CDS
      CCDS49044.1
      UniProtKB/Swiss-Prot
      G3X9F3, Q80UG6
      Related
      ENSMUSP00000070037.7, ENSMUST00000067087.7
      Conserved Domains (1) summary
      pfam15129
      Location:32150
      FAM150; FAM150 family
    2. NM_001377064.1NP_001363993.1  ALK and LTK ligand 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC160932
      Conserved Domains (1) summary
      pfam15129
      Location:32132
      FAM150; FAM150 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      30934323..30943855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)