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    Zfp595 zinc finger protein 595 [ Mus musculus (house mouse) ]

    Gene ID: 218314, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp595provided by MGI
    Official Full Name
    zinc finger protein 595provided by MGI
    Primary source
    MGI:MGI:3040707
    See related
    Ensembl:ENSMUSG00000057842 AllianceGenome:MGI:3040707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rslcan23; A230042K10Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in testis and thyroid gland. Orthologous to several human genes including ZNF493 (zinc finger protein 493); ZNF595 (zinc finger protein 595); and ZNF681 (zinc finger protein 681). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.3), limb E14.5 (RPKM 0.8) and 24 other tissues See more
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    Genomic context

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    See Zfp595 in Genome Data Viewer
    Location:
    13 B3; 13 34.54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67461049..67491018, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67312985..67342954, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F630042J09 gene Neighboring gene STARR-seq mESC enhancer starr_34898 Neighboring gene zinc finger protein 457 Neighboring gene STARR-positive B cell enhancer ABC_E3086 Neighboring gene zinc finger protein 953 Neighboring gene STARR-positive B cell enhancer ABC_E9880 Neighboring gene predicted gene 17039 Neighboring gene zinc finger protein 456 Neighboring gene STARR-positive B cell enhancer ABC_E4075 Neighboring gene zinc finger protein 429

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zin finger protein 595
    Names
    KRAB zinc finger protein
    regulator of sex-limitation candidate 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374733.1 → NP_001361662.1  zin finger protein 595 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154510, AC164116
      Consensus CDS
      CCDS88476.1
      UniProtKB/TrEMBL
      B9EIT6
      Related
      ENSMUSP00000127010.2, ENSMUST00000171466.2
      Conserved Domains (4) summary
      smart00349
      Location:2 → 60
      KRAB; krueppel associated box
      COG5048
      Location:107 → 490
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:493 → 563
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:248 → 268
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_177622.3 → NP_808290.1  zin finger protein 595 isoform 1

      See identical proteins and their annotated locations for NP_808290.1

      Status: VALIDATED

      Source sequence(s)
      AK136304, BB632383, BK001632
      Consensus CDS
      CCDS36712.1
      UniProtKB/TrEMBL
      Q8BIN6
      Related
      ENSMUSP00000105357.3, ENSMUST00000109735.9
      Conserved Domains (4) summary
      smart00349
      Location:5 → 63
      KRAB; krueppel associated box
      COG5048
      Location:110 → 493
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:496 → 566
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:251 → 271
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67461049..67491018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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