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    Lmln leishmanolysin-like (metallopeptidase M8 family) [ Mus musculus (house mouse) ]

    Gene ID: 239833, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lmlnprovided by MGI
    Official Full Name
    leishmanolysin-like (metallopeptidase M8 family)provided by MGI
    Primary source
    MGI:MGI:2444736
    See related
    Ensembl:ENSMUSG00000022802 AllianceGenome:MGI:2444736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5330415H22Rik
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in cell adhesion; cell division; and proteolysis. Predicted to be located in cytosol and focal adhesion. Predicted to be active in cytoplasm. Orthologous to human LMLN (leishmanolysin like peptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 2.2), testis adult (RPKM 2.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lmln in Genome Data Viewer
    Location:
    16 B3; 16 23.6 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32881974..32948065)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33061870..33127695)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_40679 Neighboring gene STARR-positive B cell enhancer ABC_E8628 Neighboring gene IQ motif containing G Neighboring gene STARR-positive B cell enhancer ABC_E2460 Neighboring gene ribosomal protein L35A Neighboring gene microRNA 1947 Neighboring gene predicted gene, 38540 Neighboring gene predicted gene, 41447 Neighboring gene predicted gene, 53950

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leishmanolysin-like peptidase
    NP_766411.1
    XP_030104970.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172823.2NP_766411.1  leishmanolysin-like peptidase precursor

      See identical proteins and their annotated locations for NP_766411.1

      Status: PROVISIONAL

      Source sequence(s)
      AK030463
      Consensus CDS
      CCDS28127.1
      UniProtKB/Swiss-Prot
      Q8BMN4
      Related
      ENSMUSP00000023497.3, ENSMUST00000023497.3
      Conserved Domains (1) summary
      cl19482
      Location:96628
      Peptidase_M8; Leishmanolysin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32881974..32948065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249110.1XP_030104970.1  leishmanolysin-like peptidase isoform X1

      Conserved Domains (1) summary
      cl19482
      Location:2385
      Peptidase_M8; Leishmanolysin

    RNA

    1. XR_384560.4 RNA Sequence

    2. XR_384561.4 RNA Sequence

    3. XR_384563.4 RNA Sequence

    4. XR_384562.4 RNA Sequence