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    H2-Eb2 histocompatibility 2, class II antigen E beta2 [ Mus musculus (house mouse) ]

    Gene ID: 381091, updated on 9-Dec-2024

    Summary

    Official Symbol
    H2-Eb2provided by MGI
    Official Full Name
    histocompatibility 2, class II antigen E beta2provided by MGI
    Primary source
    MGI:MGI:95902
    See related
    Ensembl:ENSMUSG00000067341 AllianceGenome:MGI:95902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ia5; Ia-5; H-2Eb2; Iebeta2; A130038H09Rik
    Summary
    Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to several human genes including HLA-DRB1 (major histocompatibility complex, class II, DR beta 1); HLA-DRB3 (major histocompatibility complex, class II, DR beta 3); and HLA-DRB4 (major histocompatibility complex, class II, DR beta 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 5.4), thymus adult (RPKM 2.6) and 4 other tissues See more
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    Genomic context

    See H2-Eb2 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34544477..34560384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34325503..34341410)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1194 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene STARR-positive B cell enhancer ABC_E2485 Neighboring gene STARR-positive B cell enhancer ABC_E397 Neighboring gene STARR-positive B cell enhancer ABC_E1505 Neighboring gene STARR-positive B cell enhancer ABC_E1940 Neighboring gene STARR-positive B cell enhancer ABC_E957 Neighboring gene STARR-seq mESC enhancer starr_42428 Neighboring gene histocompatibility 2, class II antigen E beta Neighboring gene STARR-positive B cell enhancer ABC_E8670 Neighboring gene STARR-positive B cell enhancer ABC_E8919 Neighboring gene STARR-seq mESC enhancer starr_42429 Neighboring gene STARR-positive B cell enhancer ABC_E769 Neighboring gene histocompatibility 2, class II antigen E alpha Neighboring gene STARR-positive B cell enhancer ABC_E11639 Neighboring gene butyrophilin-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CD4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MHC class II receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables polysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MHC class II protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histocompatibility 2, class II antigen E beta2
    Names
    H-2 class II histocompatibility antigen E-a/k beta-2
    MHC class II E-beta-2
    MHC class II antigen E beta2
    MHC class II antigen beta chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033978.3NP_001029150.1  histocompatibility 2, class II antigen E beta2 precursor

      See identical proteins and their annotated locations for NP_001029150.1

      Status: VALIDATED

      Source sequence(s)
      AK137912, CR974457
      Consensus CDS
      CCDS28646.1
      UniProtKB/TrEMBL
      Q3U060, Q3UUV9
      Related
      ENSMUSP00000056814.9, ENSMUST00000050325.10
      Conserved Domains (2) summary
      cd05766
      Location:125218
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      pfam00969
      Location:42115
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34544477..34560384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524489.5XP_006524552.1  histocompatibility 2, class II antigen E beta2 isoform X1

      See identical proteins and their annotated locations for XP_006524552.1

      UniProtKB/TrEMBL
      Q3U060
      Conserved Domains (3) summary
      pfam00969
      Location:42115
      MHC_II_beta; Class II histocompatibility antigen, beta domain
      pfam06364
      Location:226282
      DUF1068; Protein of unknown function (DUF1068)
      cl11960
      Location:125218
      Ig; Immunoglobulin domain
    2. XM_006524490.5XP_006524553.1  histocompatibility 2, class II antigen E beta2 isoform X2

      See identical proteins and their annotated locations for XP_006524553.1

      UniProtKB/TrEMBL
      Q3U060
      Conserved Domains (2) summary
      pfam00969
      Location:42115
      MHC_II_beta; Class II histocompatibility antigen, beta domain
      cl11960
      Location:125218
      Ig; Immunoglobulin domain