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    Plin5 perilipin 5 [ Mus musculus (house mouse) ]

    Gene ID: 66968, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plin5provided by MGI
    Official Full Name
    perilipin 5provided by MGI
    Primary source
    MGI:MGI:1914218
    See related
    Ensembl:ENSMUSG00000011305 AllianceGenome:MGI:1914218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MLDP; Lsdp5; PAT-1; 2310076L09Rik
    Summary
    Enables identical protein binding activity and lipase binding activity. Involved in several processes, including negative regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of sequestering of triglyceride; and regulation of lipid metabolic process. Located in cytosol. Colocalizes with lipid droplet. Is expressed in brown fat. Orthologous to human PLIN5 (perilipin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 44.7), adrenal adult (RPKM 29.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Plin5 in Genome Data Viewer
    Location:
    17 D; 17 29.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56418601..56424606, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56111597..56117606, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon CTC) Neighboring gene perilipin 4 Neighboring gene leucine-rich alpha-2-glycoprotein 1 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (10)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid storage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of triglyceride catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of sequestering of triglyceride IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of sequestering of triglyceride IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    perilipin-5
    Names
    lipid droplet associated protein
    lipid droplet-associated protein PAT-1
    lipid storage droplet protein 5
    myocardial LD protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077348.1NP_001070816.1  perilipin-5

      See identical proteins and their annotated locations for NP_001070816.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and encodes the same protein, compared to variant 1.
      Source sequence(s)
      AY919875, CT009719, DQ473305
      Consensus CDS
      CCDS37662.1
      UniProtKB/Swiss-Prot
      Q78IK8, Q8BVZ1
      Related
      ENSMUSP00000108695.3, ENSMUST00000113072.3
      Conserved Domains (1) summary
      pfam03036
      Location:31383
      Perilipin; Perilipin family
    2. NM_025874.3NP_080150.2  perilipin-5

      See identical proteins and their annotated locations for NP_080150.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BY101690, DQ473305
      Consensus CDS
      CCDS37662.1
      UniProtKB/Swiss-Prot
      Q78IK8, Q8BVZ1
      Related
      ENSMUSP00000019808.6, ENSMUST00000019808.12
      Conserved Domains (1) summary
      pfam03036
      Location:31383
      Perilipin; Perilipin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56418601..56424606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524805.2XP_006524868.1  perilipin-5 isoform X1

      Conserved Domains (1) summary
      pfam03036
      Location:33381
      Perilipin; Perilipin family
    2. XM_017317614.2XP_017173103.1  perilipin-5 isoform X2

      Conserved Domains (1) summary
      pfam03036
      Location:3255
      Perilipin; Perilipin family