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    Tnfaip8 tumor necrosis factor, alpha-induced protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 106869, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnfaip8provided by MGI
    Official Full Name
    tumor necrosis factor, alpha-induced protein 8provided by MGI
    Primary source
    MGI:MGI:2147191
    See related
    Ensembl:ENSMUSG00000062210 AllianceGenome:MGI:2147191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nded; Tipe; Gg2-1; Ssc-2; Gm10539; E130304C20Rik
    Summary
    Enables molecular sequestering activity and small molecule binding activity. Acts upstream of or within defense response to Gram-positive bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; choroid plexus; musculoskeletal system; respiratory system; and thymus primordium. Orthologous to human TNFAIP8 (TNF alpha induced protein 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 36.9), placenta adult (RPKM 10.3) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tnfaip8 in Genome Data Viewer
    Location:
    18 D1; 18 27.18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (50112494..50226296)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (49979427..50093229)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700065O20 gene Neighboring gene STARR-seq mESC enhancer starr_44570 Neighboring gene Dmx-like 1 Neighboring gene STARR-seq mESC enhancer starr_44572 Neighboring gene STARR-positive B cell enhancer ABC_E1957 Neighboring gene STARR-positive B cell enhancer ABC_E7584 Neighboring gene STARR-positive B cell enhancer ABC_E8716 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:50183799-50183908 Neighboring gene STARR-positive B cell enhancer ABC_E4248 Neighboring gene RIKEN cDNA C030005K06 gene Neighboring gene predicted gene, 33335 Neighboring gene STARR-positive B cell enhancer ABC_E5657 Neighboring gene STARR-positive B cell enhancer ABC_E4249 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 4 Neighboring gene CD63 antigen, pseudogene Neighboring gene predicted gene, 33376

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor alpha-induced protein 8
    Names
    TNF alpha-induced protein 8
    TNF-induced protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177759.1NP_001171230.1  tumor necrosis factor alpha-induced protein 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a distinct translation start site, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC120859, AC166570
      Consensus CDS
      CCDS50288.1
      UniProtKB/Swiss-Prot
      Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
      UniProtKB/TrEMBL
      D3YWJ5
      Related
      ENSMUSP00000120712.3, ENSMUST00000148989.3
      Conserved Domains (1) summary
      pfam05527
      Location:7185
      DUF758; Domain of unknown function (DUF758)
    2. NM_001177760.1NP_001171231.1  tumor necrosis factor alpha-induced protein 8 isoform 3

      See identical proteins and their annotated locations for NP_001171231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, and lacks an alternate segment, compared to variant 1. The resulting isoform (3z) has shorter and distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC120859, AK163339, BB623947
      Consensus CDS
      CCDS50287.1
      UniProtKB/Swiss-Prot
      Q921Z5
      Related
      ENSMUSP00000136030.2, ENSMUST00000179937.2
      Conserved Domains (1) summary
      pfam05527
      Location:7109
      DUF758; Domain of unknown function (DUF758)
    3. NM_001360935.1NP_001347864.1  tumor necrosis factor alpha-induced protein 8 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR and uses a distinct translation start site, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC120859
      UniProtKB/Swiss-Prot
      Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
      Related
      ENSMUSP00000136152.2, ENSMUST00000128377.2
      Conserved Domains (1) summary
      pfam05527
      Location:11189
      DUF758; Domain of unknown function (DUF758)
    4. NM_134131.2NP_598892.2  tumor necrosis factor alpha-induced protein 8 isoform 1

      See identical proteins and their annotated locations for NP_598892.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC120859, AK149901, BY108131
      Consensus CDS
      CCDS37817.2
      UniProtKB/Swiss-Prot
      Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
      UniProtKB/TrEMBL
      D3Z325
      Related
      ENSMUSP00000119041.3, ENSMUST00000148159.3
      Conserved Domains (1) summary
      pfam05527
      Location:51205
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      50112494..50226296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250259.1XP_030106119.1  tumor necrosis factor alpha-induced protein 8 isoform X3

      UniProtKB/Swiss-Prot
      Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
      Conserved Domains (1) summary
      pfam05527
      Location:1163
      DUF758; Domain of unknown function (DUF758)
    2. XM_006525480.2XP_006525543.1  tumor necrosis factor alpha-induced protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006525543.1

      UniProtKB/Swiss-Prot
      Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
      Conserved Domains (1) summary
      pfam05527
      Location:10188
      DUF758; Domain of unknown function (DUF758)
    3. XM_011246796.2XP_011245098.1  tumor necrosis factor alpha-induced protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011245098.1

      UniProtKB/Swiss-Prot
      Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
      UniProtKB/TrEMBL
      D3Z325
      Conserved Domains (1) summary
      pfam05527
      Location:51205
      DUF758; Domain of unknown function (DUF758)
    4. XM_036160917.1XP_036016810.1  tumor necrosis factor alpha-induced protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
      UniProtKB/TrEMBL
      D3Z325
      Conserved Domains (1) summary
      pfam05527
      Location:51205
      DUF758; Domain of unknown function (DUF758)
    5. XM_030250258.1XP_030106118.1  tumor necrosis factor alpha-induced protein 8 isoform X3

      UniProtKB/Swiss-Prot
      Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
      Conserved Domains (1) summary
      pfam05527
      Location:1163
      DUF758; Domain of unknown function (DUF758)