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    Kcnv2 potassium channel, subfamily V, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 240595, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnv2provided by MGI
    Official Full Name
    potassium channel, subfamily V, member 2provided by MGI
    Primary source
    MGI:MGI:2670981
    See related
    Ensembl:ENSMUSG00000047298 AllianceGenome:MGI:2670981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KV11.1
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in several structures, including central nervous system; heart; and retina. Human ortholog(s) of this gene implicated in retinal cone dystrophy 3B. Orthologous to human KCNV2 (potassium voltage-gated channel modifier subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 1.7), testis adult (RPKM 0.5) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcnv2 in Genome Data Viewer
    Location:
    19 C1; 19 21.88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (27299461..27314579)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (27322061..27337179)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35438 Neighboring gene STARR-seq mESC enhancer starr_45839 Neighboring gene very low density lipoprotein receptor Neighboring gene STARR-seq mESC enhancer starr_45840 Neighboring gene STARR-seq mESC enhancer starr_45841 Neighboring gene STARR-seq mESC enhancer starr_45842 Neighboring gene predicted gene, 35268 Neighboring gene STARR-seq mESC enhancer starr_45843 Neighboring gene predicted gene, 35554 Neighboring gene predicted gene, 50113

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Clone Names

    • MGC38990

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily V member 2
    Names
    voltage-gated potassium channel subunit Kv8.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183179.1NP_899002.1  potassium voltage-gated channel subfamily V member 2

      See identical proteins and their annotated locations for NP_899002.1

      Status: VALIDATED

      Source sequence(s)
      BC039042
      Consensus CDS
      CCDS29722.1
      UniProtKB/Swiss-Prot
      Q8CFS6
      Related
      ENSMUSP00000055091.4, ENSMUST00000056708.4
      Conserved Domains (4) summary
      smart00225
      Location:107198
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:305521
      Ion_trans; Ion transport protein
      pfam07885
      Location:434509
      Ion_trans_2; Ion channel
      cl02518
      Location:107198
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      27299461..27314579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527067.4XP_006527130.1  potassium voltage-gated channel subfamily V member 2 isoform X1

      Conserved Domains (2) summary
      cl38908
      Location:107214
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:276361
      Ion_trans; Ion transport protein