U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Eno4 enolase 4 [ Mus musculus (house mouse) ]

    Gene ID: 226265, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eno4provided by MGI
    Official Full Name
    enolase 4provided by MGI
    Primary source
    MGI:MGI:2441717
    See related
    Ensembl:ENSMUSG00000048029 AllianceGenome:MGI:2441717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430537H07Rik
    Summary
    Enables phosphopyruvate hydratase activity. Acts upstream of or within cilium organization; flagellated sperm motility; and glycolytic process. Located in sperm principal piece. Is expressed in choroid invagination; embryo; metencephalon part of 4th ventricle choroid plexus; and olfactory epithelium. Orthologous to human ENO4 (enolase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 4.2), lung adult (RPKM 0.5) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eno4 in Genome Data Viewer
    Location:
    19 D2; 19 54.55 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (58922490..58959853)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (58934058..58971421)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 12A Neighboring gene predicted gene, 52393 Neighboring gene STARR-seq mESC enhancer starr_46588 Neighboring gene microRNA 3086 Neighboring gene STARR-seq mESC enhancer starr_46589 Neighboring gene shootin 1 Neighboring gene predicted gene, 57667

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Clone Names

    • MGC30738

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphopyruvate hydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    enolase 4
    Names
    2-phospho-D-glycerate hydro-lyase
    enolase-like protein C10orf134 homolog
    enolase-like protein ENO4
    NP_848804.2
    XP_006527117.1
    XP_006527118.1
    XP_006527119.1
    XP_030106782.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178689.5NP_848804.2  enolase 4

      Status: VALIDATED

      Source sequence(s)
      AC102604
      Consensus CDS
      CCDS79725.1
      UniProtKB/Swiss-Prot
      E9QLA7, Q8BVS9, Q8C042, Q8CFL9
      UniProtKB/TrEMBL
      A0A0J9YUP0
      Related
      ENSMUSP00000144272.2, ENSMUST00000200910.4
      Conserved Domains (2) summary
      TIGR01060
      Location:68570
      eno; phosphopyruvate hydratase
      cl21457
      Location:236569
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      58922490..58959853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527054.4XP_006527117.1  enolase 4 isoform X1

      UniProtKB/Swiss-Prot
      E9QLA7, Q8BVS9, Q8C042, Q8CFL9
      Conserved Domains (1) summary
      TIGR01060
      Location:68570
      eno; phosphopyruvate hydratase
    2. XM_006527055.4XP_006527118.1  enolase 4 isoform X2

      UniProtKB/Swiss-Prot
      E9QLA7, Q8BVS9, Q8C042, Q8CFL9
      Conserved Domains (1) summary
      TIGR01060
      Location:68507
      eno; phosphopyruvate hydratase
    3. XM_006527056.4XP_006527119.1  enolase 4 isoform X3

      UniProtKB/Swiss-Prot
      E9QLA7, Q8BVS9, Q8C042, Q8CFL9
      Conserved Domains (1) summary
      TIGR01060
      Location:68507
      eno; phosphopyruvate hydratase
    4. XM_030250922.1XP_030106782.1  enolase 4 isoform X4

      UniProtKB/TrEMBL
      A0A0J9YVG9
      Related
      ENSMUSP00000144656.2, ENSMUST00000202382.4
      Conserved Domains (1) summary
      TIGR01060
      Location:2333
      eno; phosphopyruvate hydratase