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    Pithd1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 66193, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pithd1provided by MGI
    Official Full Name
    PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1provided by MGI
    Primary source
    MGI:MGI:1913443
    See related
    Ensembl:ENSMUSG00000028669 AllianceGenome:MGI:1913443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trp26; 1110049F12Rik
    Summary
    Involved in positive regulation of megakaryocyte differentiation. Acts upstream of or within several processes, including penetration of cumulus oophorus; penetration of zona pellucida; and regulation of proteasomal protein catabolic process. Located in sperm cytoplasmic droplet. Is expressed in several structures, including central nervous system; ganglia; nose; respiratory system; and tooth. Orthologous to human PITHD1 (PITH domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 52.8), colon adult (RPKM 47.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pithd1 in Genome Data Viewer
    Location:
    4 D3; 4 68.34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135702913..135714555, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135975602..135987244, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3529 Neighboring gene galactose-4-epimerase, UDP Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135528566-135528675 Neighboring gene lysophospholipase 2 Neighboring gene predicted gene 13007 Neighboring gene elongin A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm cytoplasmic droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    PITH domain-containing protein 1
    Names
    AD039
    thioredoxin family Trp26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025411.4NP_079687.3  PITH domain-containing protein 1

      See identical proteins and their annotated locations for NP_079687.3

      Status: VALIDATED

      Source sequence(s)
      BC052695, BY044314
      Consensus CDS
      CCDS51330.1
      UniProtKB/Swiss-Prot
      Q8BMZ1, Q8BWR2
      Related
      ENSMUSP00000101477.3, ENSMUST00000105851.9
      Conserved Domains (1) summary
      pfam06201
      Location:35175
      PITH; PITH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135702913..135714555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)