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    Hopx HOP homeobox [ Mus musculus (house mouse) ]

    Gene ID: 74318, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hopxprovided by MGI
    Official Full Name
    HOP homeoboxprovided by MGI
    Primary source
    MGI:MGI:1916782
    See related
    Ensembl:ENSMUSG00000059325 AllianceGenome:MGI:1916782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hod; Hop; Ob1; Obl; Hdop; Toto; Cameo; 1110018K11Rik; 1200015P04Rik; 2300002F06Rik
    Summary
    Enables histone deacetylase regulator activity. Involved in positive regulation of gap junction assembly. Acts upstream of or within several processes, including lung alveolus development; positive regulation of skeletal muscle tissue regeneration; and trophectodermal cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; heart; lung; trophectoderm; and urinary system. Orthologous to human HOPX (HOP homeobox). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 209.4), heart adult (RPKM 74.9) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hopx in Genome Data Viewer
    Location:
    5 C3.3; 5 41.45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (77234831..77262970, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (77086986..77115123, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700112J05 gene Neighboring gene sperm microtubule associated protein 2 like Neighboring gene STARR-seq mESC enhancer starr_13457 Neighboring gene STARR-seq mESC enhancer starr_13458 Neighboring gene microRNA 12199 Neighboring gene predicted gene, 57746 Neighboring gene HOP homeobox, opposite strand Neighboring gene STARR-seq mESC enhancer starr_13459 Neighboring gene STARR-seq mESC enhancer starr_13460 Neighboring gene predicted gene 15831 Neighboring gene VISTA enhancer mm770 Neighboring gene STARR-seq mESC enhancer starr_13461 Neighboring gene predicted gene, 34598

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase regulator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gap junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of striated muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within trophectodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    homeodomain-only protein
    Names
    homeobox only domain
    homeobox-only protein
    mOB1
    odd homeobox 1
    odd homeobox protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159900.1NP_001153372.1  homeodomain-only protein

      See identical proteins and their annotated locations for NP_001153372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AK003784, BB598275, BM123896, CO044889
      Consensus CDS
      CCDS39120.1
      UniProtKB/Swiss-Prot
      Q8C1N5, Q8CJ22, Q8R1H0
      Related
      ENSMUSP00000109080.3, ENSMUST00000113453.9
      Conserved Domains (1) summary
      cd00086
      Location:1062
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    2. NM_001159901.1NP_001153373.1  homeodomain-only protein

      See identical proteins and their annotated locations for NP_001153373.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AI604115, AK009007, BB598275, BE956264, BM123896
      Consensus CDS
      CCDS39120.1
      UniProtKB/Swiss-Prot
      Q8C1N5, Q8CJ22, Q8R1H0
      Related
      ENSMUSP00000113295.3, ENSMUST00000120827.9
      Conserved Domains (1) summary
      cd00086
      Location:1062
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    3. NM_175606.3NP_783199.1  homeodomain-only protein

      See identical proteins and their annotated locations for NP_783199.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AF534182, AK009007, BE956264, BM123896
      Consensus CDS
      CCDS39120.1
      UniProtKB/Swiss-Prot
      Q8C1N5, Q8CJ22, Q8R1H0
      Related
      ENSMUSP00000080630.5, ENSMUST00000081964.7
      Conserved Domains (1) summary
      cd00086
      Location:1062
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      77234831..77262970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165564.1XP_036021457.1  homeodomain-only protein isoform X1

      UniProtKB/Swiss-Prot
      Q8C1N5, Q8CJ22, Q8R1H0
      Conserved Domains (1) summary
      cd00086
      Location:1062
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.