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    Gak cyclin G associated kinase [ Mus musculus (house mouse) ]

    Gene ID: 231580, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gakprovided by MGI
    Official Full Name
    cyclin G associated kinaseprovided by MGI
    Primary source
    MGI:MGI:2442153
    See related
    Ensembl:ENSMUSG00000062234 AllianceGenome:MGI:2442153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130045N16Rik
    Summary
    Predicted to enable clathrin binding activity and cyclin binding activity. Acts upstream of or within several processes, including epithelial cell differentiation; establishment of skin barrier; and intrahepatic bile duct development. Predicted to be located in Golgi apparatus and clathrin-coated vesicle. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Is expressed in several structures, including central nervous system; liver; and retina. Orthologous to human GAK (cyclin G associated kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 34.6), large intestine adult (RPKM 29.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gak in Genome Data Viewer
    Location:
    5 F; 5 53.2 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108716973..108777643, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108569107..108629777, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13909 Neighboring gene ribosomal protein L34 pseudogene Neighboring gene complexin 1 Neighboring gene transmembrane protein 175 Neighboring gene diacylglycerol kinase, theta Neighboring gene iduronidase, alpha-L Neighboring gene solute carrier family 26 (sulfate transporter), member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC31204, D130045N16Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin coat disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within clathrin coat disassembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in clathrin coat disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-dependent endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within intrahepatic bile duct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuroepithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of clathrin coat assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cyclin-G-associated kinase
    Names
    dnaJ homolog subfamily C member 26
    NP_001268980.1
    NP_001268981.1
    NP_001346851.1
    NP_001346852.1
    NP_001346853.1
    NP_705797.1
    XP_006534968.1
    XP_036020971.1
    XP_036020972.1
    XP_036020973.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282051.1NP_001268980.1  cyclin-G-associated kinase isoform 2

      See identical proteins and their annotated locations for NP_001268980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
      Source sequence(s)
      AC133896, AI466057, AK166682, BC065109, BY312464
      UniProtKB/TrEMBL
      Q3UDE5
      Conserved Domains (4) summary
      cd06257
      Location:10921137
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:5521008
      Atrophin-1; Atrophin-1 family
    2. NM_001282052.1NP_001268981.1  cyclin-G-associated kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC133896, AI466057, AK166682, BC062975, BY312464
      UniProtKB/TrEMBL
      Q3UDE5
      Conserved Domains (3) summary
      cd06257
      Location:10411086
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:356494
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:1108
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001359922.1NP_001346851.1  cyclin-G-associated kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC133896, AC161813
      UniProtKB/TrEMBL
      Q3UDE5
      Conserved Domains (5) summary
      cd06257
      Location:10431088
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:777930
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:631964
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    4. NM_001359923.1NP_001346852.1  cyclin-G-associated kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161813, AK051394
      UniProtKB/TrEMBL
      Q3UDE5
      Related
      ENSMUST00000137872.8
      Conserved Domains (2) summary
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001359924.1NP_001346853.1  cyclin-G-associated kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC133896, AC161813, AK150112
      UniProtKB/TrEMBL
      Q3UDE5
      Conserved Domains (4) summary
      cd06257
      Location:10921137
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:407545
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1159
      PKc_like; Protein Kinases, catalytic domain
      cl26464
      Location:5521008
      Atrophin-1; Atrophin-1 family
    6. NM_153569.2NP_705797.1  cyclin-G-associated kinase isoform 1

      See identical proteins and their annotated locations for NP_705797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC133896, AI466057, AK166682, BY312464
      Consensus CDS
      CCDS19513.1
      UniProtKB/Swiss-Prot
      Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4, Q99KY4
      UniProtKB/TrEMBL
      A0A0R4J0F6, Q3UIZ0
      Related
      ENSMUSP00000036705.9, ENSMUST00000046603.15
      Conserved Domains (4) summary
      cd06257
      Location:12531298
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:568706
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108716973..108777643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534905.4XP_006534968.1  cyclin-G-associated kinase isoform X1

      UniProtKB/Swiss-Prot
      Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4, Q99KY4
      UniProtKB/TrEMBL
      Q3UIZ0
      Conserved Domains (5) summary
      cd06257
      Location:12041249
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PHA03247
      Location:9381091
      PHA03247; large tegument protein UL36; Provisional
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      cd14564
      Location:398560
      PTP_GAK; protein tyrosine phosphatase-like domain of cyclin-G-associated kinase
      pfam10409
      Location:568706
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    2. XM_036165079.1XP_036020972.1  cyclin-G-associated kinase isoform X2

      Conserved Domains (3) summary
      cd06257
      Location:774819
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PHA03247
      Location:234690
      PHA03247; large tegument protein UL36; Provisional
      pfam10409
      Location:89227
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    3. XM_036165078.1XP_036020971.1  cyclin-G-associated kinase isoform X2

      Conserved Domains (3) summary
      cd06257
      Location:774819
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PHA03247
      Location:234690
      PHA03247; large tegument protein UL36; Provisional
      pfam10409
      Location:89227
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    4. XM_036165080.1XP_036020973.1  cyclin-G-associated kinase isoform X3

      Conserved Domains (3) summary
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      cd14564
      Location:398560
      PTP_GAK; protein tyrosine phosphatase-like domain of cyclin-G-associated kinase
      pfam10409
      Location:568683
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    RNA

    1. XR_003955633.2 RNA Sequence

    2. XR_389271.5 RNA Sequence

      Related
      ENSMUST00000135225.8
    3. XR_001784677.3 RNA Sequence

      Related
      ENSMUST00000199048.5
    4. XR_004942505.1 RNA Sequence