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    Dgkq diacylglycerol kinase, theta [ Mus musculus (house mouse) ]

    Gene ID: 110524, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dgkqprovided by MGI
    Official Full Name
    diacylglycerol kinase, thetaprovided by MGI
    Primary source
    MGI:MGI:102918
    See related
    Ensembl:ENSMUSG00000004815 AllianceGenome:MGI:102918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAGK; Dgkd; DAGK7; Dagk4; 110kDa
    Summary
    Predicted to enable several functions, including ATP-dependent diacylglycerol kinase activity; enzyme binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in regulation of synaptic vesicle endocytosis. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human DGKQ (diacylglycerol kinase theta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 17.4), duodenum adult (RPKM 15.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dgkq in Genome Data Viewer
    Location:
    5 F; 5 53.24 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108794910..108808696, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108647044..108660830, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13909 Neighboring gene complexin 1 Neighboring gene cyclin G associated kinase Neighboring gene transmembrane protein 175 Neighboring gene iduronidase, alpha-L Neighboring gene solute carrier family 26 (sulfate transporter), member 1 Neighboring gene predicted gene, 42151

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent diacylglycerol kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alkylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane receptor protein tyrosine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to bile acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diacylglycerol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glycerolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycerolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cortisol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cortisol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of progesterone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of progesterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thrombin-activated receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thrombin-activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    diacylglycerol kinase theta
    Names
    DAG kinase theta
    DGK-theta
    Dgk theta
    diacylglycerol kinase, delta (110 kDa)
    diglyceride kinase theta
    NP_001343958.1
    NP_950176.1
    XP_006534789.1
    XP_011247694.1
    XP_030109915.1
    XP_030109916.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357029.1NP_001343958.1  diacylglycerol kinase theta isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC161813
      Conserved Domains (4) summary
      smart00045
      Location:498650
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:347471
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd01783
      Location:154248
      RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
      cd17111
      Location:58151
      RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
    2. NM_199011.2NP_950176.1  diacylglycerol kinase theta isoform 1

      See identical proteins and their annotated locations for NP_950176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161813, BC062929
      Consensus CDS
      CCDS19515.1
      UniProtKB/Swiss-Prot
      Q3UYE8, Q6P5E8
      Related
      ENSMUSP00000057859.7, ENSMUST00000053913.13
      Conserved Domains (6) summary
      TIGR00147
      Location:582904
      TIGR00147; lipid kinase, YegS/Rv2252/BmrU family
      smart00109
      Location:178228
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00045
      Location:733885
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:582706
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:55102
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl00155
      Location:388483
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108794910..108808696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249392.2XP_011247694.1  diacylglycerol kinase theta isoform X1

      Conserved Domains (6) summary
      smart00109
      Location:178228
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00045
      Location:738890
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:587711
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:55102
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01783
      Location:389483
      RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
      cd17111
      Location:293386
      RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
    2. XM_030254055.2XP_030109915.1  diacylglycerol kinase theta isoform X2

      Conserved Domains (4) summary
      smart00045
      Location:503655
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:352476
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd01783
      Location:154248
      RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
      cd17111
      Location:58151
      RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
    3. XM_006534726.4XP_006534789.1  diacylglycerol kinase theta isoform X3

      Conserved Domains (4) summary
      smart00109
      Location:178228
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00029
      Location:55102
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01783
      Location:389483
      RA2_DAGK-theta; Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
      cd17111
      Location:293386
      RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
    4. XM_030254056.2XP_030109916.1  diacylglycerol kinase theta isoform X4

      Conserved Domains (5) summary
      smart00109
      Location:178228
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00029
      Location:55102
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17111
      Location:293386
      RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
      cl00040
      Location:125162
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28922
      Location:389474
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RNA

    1. XR_001784590.2 RNA Sequence

      Related
      ENSMUST00000144624.8
    2. XR_001784589.2 RNA Sequence

      Related
      ENSMUST00000153238.8
    3. XR_001784588.2 RNA Sequence

    4. XR_004942423.1 RNA Sequence

      Related
      ENSMUST00000153365.8
    5. XR_004942422.1 RNA Sequence

    6. XR_003955570.2 RNA Sequence

      Related
      ENSMUST00000132179.8
    7. XR_003955571.1 RNA Sequence