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    Slc26a1 solute carrier family 26 (sulfate transporter), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 231583, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc26a1provided by MGI
    Official Full Name
    solute carrier family 26 (sulfate transporter), member 1provided by MGI
    Primary source
    MGI:MGI:2385894
    See related
    Ensembl:ENSMUSG00000046959 AllianceGenome:MGI:2385894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sat1
    Summary
    Enables chloride transmembrane transporter activity; oxalate transmembrane transporter activity; and sulfate:bicarbonate antiporter activity. Involved in chloride transport; oxalate transport; and sulfate transmembrane transport. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; integumental system; liver; nose; and urinary system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 59.7), kidney adult (RPKM 58.5) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc26a1 in Genome Data Viewer
    Location:
    5 F; 5 53.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108817744..108826246, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108669878..108678380, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cyclin G associated kinase Neighboring gene transmembrane protein 175 Neighboring gene diacylglycerol kinase, theta Neighboring gene iduronidase, alpha-L Neighboring gene predicted gene, 42151 Neighboring gene fibroblast growth factor receptor-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within oxalate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oxalate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within sulfate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sulfate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sulfate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sulfate anion transporter 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310691.1NP_001297620.1  sulfate anion transporter 1 isoform 1

      See identical proteins and their annotated locations for NP_001297620.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161813
      Consensus CDS
      CCDS80355.1
      UniProtKB/TrEMBL
      G5E8U1, Q8R4W9
      Related
      ENSMUSP00000113185.2, ENSMUST00000119270.2
      Conserved Domains (2) summary
      cd07042
      Location:554686
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:71702
      sulP; high affinity sulphate transporter 1
    2. NM_001310692.1NP_001297621.1  sulfate anion transporter 1 isoform 2

      See identical proteins and their annotated locations for NP_001297621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a segment in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC161813
      Consensus CDS
      CCDS19517.1
      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Related
      ENSMUSP00000131282.2, ENSMUST00000163328.8
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1
    3. NM_174870.4NP_777359.3  sulfate anion transporter 1 isoform 2

      See identical proteins and their annotated locations for NP_777359.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC161813, AK143528
      Consensus CDS
      CCDS19517.1
      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Related
      ENSMUSP00000051561.8, ENSMUST00000051757.14
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108817744..108826246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254412.1XP_030110272.1  sulfate anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1
    2. XM_017320856.2XP_017176345.1  sulfate anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1
    3. XM_036165081.1XP_036020974.1  sulfate anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1
    4. XM_030254414.1XP_030110274.1  sulfate anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1
    5. XM_030254411.1XP_030110271.1  sulfate anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1
    6. XM_017320855.2XP_017176344.1  sulfate anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1
    7. XM_030254413.2XP_030110273.1  sulfate anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1
    8. XM_036165082.1XP_036020975.1  sulfate anion transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P58735, Q80WF6
      UniProtKB/TrEMBL
      Q3UPH6, Q8R4W9
      Conserved Domains (1) summary
      TIGR00815
      Location:55686
      sulP; high affinity sulphate transporter 1