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    Rnf148 ring finger protein 148 [ Mus musculus (house mouse) ]

    Gene ID: 71300, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf148provided by MGI
    Official Full Name
    ring finger protein 148provided by MGI
    Primary source
    MGI:MGI:1918550
    See related
    Ensembl:ENSMUSG00000078179 AllianceGenome:MGI:1918550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Greul3; 4933432M07Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and late endosome. Orthologous to human RNF148 (ring finger protein 148). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Rnf148 in Genome Data Viewer
    Location:
    6 A3.1; 6 11.01 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (23653894..23655135, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (23653895..23655136, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Ca2+-dependent activator protein for secretion 2 Neighboring gene predicted gene, 38775 Neighboring gene ring finger protein 133 Neighboring gene STARR-seq mESC enhancer starr_15338 Neighboring gene cell division cycle 20 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_15339 Neighboring gene STARR-seq mESC enhancer starr_15340 Neighboring gene STARR-seq mESC enhancer starr_15342 Neighboring gene taste receptor, type 2, member 118

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice. Nozawa K, et al. BMC Biol, 2022 Jul 13. PMID 35831855, Free PMC Article
    2. The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development. Borchers AG, et al. Dev Biol, 2002 Nov 15. PMID 12435366
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 148
    Names
    goliath-related E3 ubiquitin-protein ligase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027754.1 → NP_082030.1  RING finger protein 148 precursor

      See identical proteins and their annotated locations for NP_082030.1

      Status: VALIDATED

      Source sequence(s)
      AC155850, AK017027, AV265669
      Consensus CDS
      CCDS51726.1
      UniProtKB/Swiss-Prot
      G3X9R7, Q8CGR1, Q9D3V4
      Related
      ENSMUSP00000100592.2, ENSMUST00000104979.2
      Conserved Domains (2) summary
      cd02122
      Location:56 → 190
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:267 → 310
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      23653894..23655135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3X9R7.1 GenPept UniProtKB/Swiss-Prot:G3X9R7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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