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    Trir telomerase RNA component interacting RNase [ Mus musculus (house mouse) ]

    Gene ID: 68544, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trirprovided by MGI
    Official Full Name
    telomerase RNA component interacting RNaseprovided by MGI
    Primary source
    MGI:MGI:1922833
    See related
    Ensembl:ENSMUSG00000041203 AllianceGenome:MGI:1922833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110002H14Rik; 2310036O22Rik
    Summary
    Predicted to enable 3'-5' exonuclease activity and 5'-3' exonuclease activity. Predicted to be involved in rRNA catabolic process. Orthologous to human TRIR (telomerase RNA component interacting RNase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 80.0), CNS E14 (RPKM 55.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Trir in Genome Data Viewer
    Location:
    8 C3; 8 41.49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85753440..85756920)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85026811..85030291)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene bestrophin 2 Neighboring gene STARR-seq mESC enhancer starr_22148 Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene STARR-positive B cell enhancer ABC_E884 Neighboring gene STARR-positive B cell enhancer ABC_E8254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87560506-87560689 Neighboring gene transportin 2 (importin 3, karyopherin beta 2b) Neighboring gene RIKEN cDNA A230103J11 gene Neighboring gene predicted gene, 25506 Neighboring gene STARR-seq mESC enhancer starr_22150 Neighboring gene F-box and WD-40 domain protein 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 5'-3' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 5'-3' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 5'-3' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    telomerase RNA component interacting RNase
    Names
    exoribonuclease Trir
    exoribonuclease TrirR
    uncharacterized protein C19orf43 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026760.3NP_081036.2  telomerase RNA component interacting RNase

      See identical proteins and their annotated locations for NP_081036.2

      Status: VALIDATED

      Source sequence(s)
      AC163703
      Consensus CDS
      CCDS22490.1
      UniProtKB/Swiss-Prot
      Q9D1N3, Q9D735
      Related
      ENSMUSP00000044129.9, ENSMUST00000047281.10

    RNA

    1. NR_160793.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163703

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85753440..85756920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243748.1XP_030099608.1  telomerase RNA component interacting RNase isoform X2

    2. XM_030243747.2XP_030099607.1  telomerase RNA component interacting RNase isoform X1