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    Dpep1 dipeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 13479, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dpep1provided by MGI
    Official Full Name
    dipeptidase 1provided by MGI
    Primary source
    MGI:MGI:94917
    See related
    Ensembl:ENSMUSG00000019278 AllianceGenome:MGI:94917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBD; DPEP-1
    Summary
    Enables beta-lactamase activity and dipeptidase activity. Involved in several processes, including glutathione catabolic process; leukotriene metabolic process; and neutrophil chemotaxis. Predicted to be located in several cellular components, including apical part of cell; extracellular space; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in genitourinary system; incisor; and lung. Human ortholog(s) of this gene implicated in hepatoblastoma. Orthologous to human DPEP1 (dipeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 182.7), small intestine adult (RPKM 109.8) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Dpep1 in Genome Data Viewer
    Location:
    8 E1; 8 72.08 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123913069..123928551)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123186235..123201812)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57791 Neighboring gene predicted gene 4316 Neighboring gene charged multivesicular body protein 1A Neighboring gene ribosomal protein S12, pseudogene 9 Neighboring gene spermatogenesis associated 33

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GPI anchor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables beta-lactamase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-lactamase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dipeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallodipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallodipeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables modified amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables modified amino acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in antibiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antibiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antibiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to nitric oxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glutathione catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homocysteine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukotriene D4 catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukotriene D4 catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in leukotriene metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leukotriene metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dipeptidase 1
    Names
    MBD-1
    beta-lactamase
    dipeptidase 1 (renal)
    membrane bound dipeptidase type II
    membrane-bound dipeptidase 1
    microsomal dipeptidase
    renal dipeptidase
    NP_001403941.1
    NP_031902.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417012.1NP_001403941.1  dipeptidase 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC163617
      UniProtKB/Swiss-Prot
      G5E824, P31428
      UniProtKB/TrEMBL
      Q99LA8
    2. NM_007876.3NP_031902.2  dipeptidase 1 precursor

      See identical proteins and their annotated locations for NP_031902.2

      Status: VALIDATED

      Source sequence(s)
      AC163617
      Consensus CDS
      CCDS22750.1
      UniProtKB/Swiss-Prot
      G5E824, P31428
      UniProtKB/TrEMBL
      Q99LA8
      Related
      ENSMUSP00000019422.5, ENSMUST00000019422.6
      Conserved Domains (1) summary
      pfam01244
      Location:25352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123913069..123928551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)