Fam220a family with sequence similarity 220, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fam220aprovided by MGI
Official Full Name: family with sequence similarity 220, member Aprovided by MGI
Primary source: MGI:MGI:1914488
See related: Ensembl:ENSMUSG00000083012 AllianceGenome:MGI:1914488
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sipar; Acpin1; 1500026F15Rik; 2810453I06Rik
Summary: Enables STAT family protein binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and protein dephosphorylation. Located in acrosomal vesicle and nucleus. Orthologous to several human genes including FAM220A (family with sequence similarity 220 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 61.1), spleen adult (RPKM 25.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 82.27 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (143534475..143550286)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (143548720..143564531)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tgfb2 and Fam220a were identified as putative targets of miR-489-3p and miR-92a-3p, respectively; inhibition endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis
Title: Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis.
results suggest that SIPAR terminates the activation of STAT3 through a dephosphorylation process that is dependent upon interaction with TC45 in the nucleus
Title: Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP.
SIPAR, functioning as a new negative regulator, inhibits STAT3 activity by enhancing its dephosphorylation and represses melanoma progression.
Title: SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma.
The two ORFs on the Acpin1 mRNA are independently translated in differentiated cells
Title: Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables STAT family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables STAT family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein FAM220A

Names: STAT3-interacting protein as a repressor; acrosomal protein ACPIN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.