Haus7 HAUS augmin-like complex, subunit 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Haus7provided by MGI
Official Full Name: HAUS augmin-like complex, subunit 7provided by MGI
Primary source: MGI:MGI:1920988
See related: Ensembl:ENSMUSG00000031371 AllianceGenome:MGI:1920988
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Uip1; Uchl5ip; 1110020L19Rik
Summary: Predicted to enable microtubule minus-end binding activity and thioesterase binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in microtubule cytoskeleton; nucleolus; and plasma membrane. Predicted to be part of HAUS complex. Orthologous to human HAUS7 (HAUS augmin like complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 18.5), CNS E11.5 (RPKM 17.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.32 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (72480921..72502635, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (73437315..73459029, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest Uchl5ip has role in spindle formation in oocyte meiotic maturation; Uchl5ip protein level is consistent during metaphase I/II; Uchl5ip localizes to meiotic spindle; loss of Uchl5ip disrupts localization of gamma-tubulin to spindle poles.
Title: Knockdown of UCHL5IP causes abnormalities in γ-tubulin localisation, spindle organisation and chromosome alignment in mouse oocyte meiotic maturation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info
enables thioesterase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule organizing center organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in spindle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of HAUS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HAUS complex	ISO Inferred from Sequence Orthology more info
part_of HAUS complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: HAUS augmin-like complex subunit 7

Names: 26S proteasome-associated UCH37-interacting protein 1; UCH37-interacting protein 1; UCHL5-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.