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    Tsc22d3 TSC22 domain family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 14605, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tsc22d3provided by MGI
    Official Full Name
    TSC22 domain family, member 3provided by MGI
    Primary source
    MGI:MGI:1196284
    See related
    Ensembl:ENSMUSG00000031431 AllianceGenome:MGI:1196284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIP; Gilz; Dsip1; Tilz3; TSC-22R
    Summary
    Acts upstream of or within negative regulation of activation-induced cell death of T cells and response to osmotic stress. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; sensory organ; and viscerocranium. Orthologous to human TSC22D3 (TSC22 domain family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 50.5), lung adult (RPKM 48.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tsc22d3 in Genome Data Viewer
    Location:
    X F1; X 61.35 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (139440277..139501257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140539528..140600522, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chrX:136990945-136991245 Neighboring gene STARR-seq mESC enhancer starr_48006 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 Neighboring gene STARR-positive B cell enhancer mm9_chrX:137038534-137038835 Neighboring gene predicted gene, 39538 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene midline 2 Neighboring gene predicted gene, 23199

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    TSC22 domain family protein 3
    Names
    TSC22-related inducible leucine zipper 3
    delta sleep inducing peptide, immunoreactor
    glucocorticoid-induced leucine zipper protein
    long glucocorticoid-induced leucine zipper protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077364.2NP_001070832.1  TSC22 domain family protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001070832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL683809
      Consensus CDS
      CCDS41150.1
      UniProtKB/Swiss-Prot
      Q9Z2S7
      Related
      ENSMUSP00000108620.3, ENSMUST00000112996.9
      Conserved Domains (1) summary
      pfam01166
      Location:122178
      TSC22; TSC-22/dip/bun family
    2. NM_010286.6NP_034416.3  TSC22 domain family protein 3 isoform 2

      See identical proteins and their annotated locations for NP_034416.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL683809
      Consensus CDS
      CCDS30440.1
      UniProtKB/Swiss-Prot
      B1AVF3, C6EX03, Q3UNI6, Q8K160, Q9EQN0, Q9EQN1, Q9EQN2, Q9Z2S7
      Conserved Domains (1) summary
      cd21940
      Location:57137
      ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3

    RNA

    1. NR_122039.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL683809
      Related
      ENSMUST00000112995.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      139440277..139501257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528504.4XP_006528567.1  TSC22 domain family protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528567.1

      UniProtKB/Swiss-Prot
      Q9Z2S7
      Conserved Domains (1) summary
      pfam01166
      Location:122178
      TSC22; TSC-22/dip/bun family
    2. XM_006528499.5XP_006528562.1  TSC22 domain family protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528562.1

      UniProtKB/Swiss-Prot
      Q9Z2S7
      Conserved Domains (1) summary
      pfam01166
      Location:122178
      TSC22; TSC-22/dip/bun family
    3. XM_006528500.4XP_006528563.1  TSC22 domain family protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528563.1

      UniProtKB/Swiss-Prot
      Q9Z2S7
      Conserved Domains (1) summary
      pfam01166
      Location:122178
      TSC22; TSC-22/dip/bun family
    4. XM_006528505.5XP_006528568.1  TSC22 domain family protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528568.1

      UniProtKB/Swiss-Prot
      Q9Z2S7
      Conserved Domains (1) summary
      pfam01166
      Location:122178
      TSC22; TSC-22/dip/bun family
    5. XM_036161820.1XP_036017713.1  TSC22 domain family protein 3 isoform X2

      UniProtKB/Swiss-Prot
      B1AVF3, C6EX03, Q3UNI6, Q8K160, Q9EQN0, Q9EQN1, Q9EQN2, Q9Z2S7
      Related
      ENSMUSP00000062589.5, ENSMUST00000055738.12
      Conserved Domains (1) summary
      cd21940
      Location:57137
      ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3
    6. XM_006528503.4XP_006528566.1  TSC22 domain family protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006528566.1

      UniProtKB/Swiss-Prot
      Q9Z2S7
      Conserved Domains (1) summary
      pfam01166
      Location:157
      TSC22; TSC-22/dip/bun family