Plvap plasmalemma vesicle associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plvapprovided by RGD
Official Full Name: plasmalemma vesicle associated proteinprovided by RGD
Primary source: RGD:619971
See related: EnsemblRapid:ENSRNOG00000017676 AllianceGenome:RGD:619971
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pv1
Summary: Enables identical protein binding activity. Predicted to be involved in several processes, including MAPK cascade; positive regulation of cellular extravasation; and tumor necrosis factor-mediated signaling pathway. Located in caveola. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PLVAP (plasmalemma vesicle associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 1700.7), Spleen (RPKM 596.1) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18218966..18231279, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18184985..18197301, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (19906354..19918668, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that PV-1 was detected exclusively over highly permeable regions of the brain by in situ hybridization.
Title: Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus.
tested the role of PV1 in the structure of the diaphragms and demonstrated that multiple PV1 homodimers reside in close proximity within the same diaphragm.
Title: Multiple PV1 dimers reside in the same stomatal or fenestral diaphragm.
PV-1 is developmentally regulated in the rat lung and shows a divergent intracellular localization, with a limited caveolae/Cav-1 colocalization in cultured endothelial cells.
Title: Developmental regulation of PV-1 in rat lung: association with the nuclear envelope and limited colocalization with Cav-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in developmental process	ISO Inferred from Sequence Orthology more info
involved_in developmental process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cellular extravasation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	NAS Non-traceable Author Statement more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plasmalemma vesicle-associated protein

Names: PV-1; gp68; plasmalemma vesicle protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.