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    Flii FLII, actin remodeling protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287375, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fliiprovided by RGD
    Official Full Name
    FLII, actin remodeling proteinprovided by RGD
    Primary source
    RGD:1307590
    See related
    EnsemblRapid:ENSRNOG00000004159 AllianceGenome:RGD:1307590
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fliih
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin cytoskeleton organization; actin filament severing; and barbed-end actin filament capping. Predicted to be located in several cellular components, including brush border; centriolar satellite; and nucleoplasm. Predicted to be active in actin cytoskeleton; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 341.5), Heart (RPKM 328.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Flii in Genome Data Viewer
    Location:
    10q22
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45893566..45907547, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45394032..45408051, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46955460..46969468, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene myosin XVA Neighboring gene U7 small nuclear RNA Neighboring gene alkB homolog 5, RNA demethylase Neighboring gene ribosomal protein L17 like 5 Neighboring gene LLGL scribble cell polarity complex component 1 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene mitochondrial elongation factor 2 Neighboring gene DNA topoisomerase III alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing. Lin CH, et al. Mamm Genome, 2011 Jun. PMID 21400204
    2. Regeneration of hair follicles is modulated by flightless I (Flii) in a rodent vibrissa model. Waters JM, et al. J Invest Dermatol, 2011 Apr. PMID 21191408
    3. Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. Campbell HD, et al. Mol Cell Biol, 2002 May. PMID 11971982, Free PMC Article
    4. Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. Liu YT, et al. J Biol Chem, 1998 Apr 3. PMID 9525888
    5. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreased expression of Flightless I in early-gestation fetal wounds improves healing.
      Title: Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing.
    2. Flii appears to have a positive role in the regeneration of hair follicles, contrary to its negative influence on wound healing in skin
      Title: Regeneration of hair follicles is modulated by flightless I (Flii) in a rodent vibrissa model.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94344

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein flightless-1 homolog
    Names
    flightless I actin binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008279.1 → NP_001008280.1  protein flightless-1 homolog

      See identical proteins and their annotated locations for NP_001008280.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085829
      UniProtKB/TrEMBL
      Q5RKI5
      Related
      ENSRNOP00000006753.6, ENSRNOT00000006753.7
      Conserved Domains (8) summary
      cd11280
      Location:619 → 703
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1054 → 1153
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:492 → 604
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:1164 → 1263
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:723 → 837
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd00116
      Location:89 → 375
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:106 → 128
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:131 → 186
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      45893566..45907547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246468.5 → XP_006246530.1  protein flightless-1 homolog isoform X1

      UniProtKB/TrEMBL
      F7F0E5
      Conserved Domains (8) summary
      cd11280
      Location:618 → 702
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1053 → 1152
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:491 → 603
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:1163 → 1262
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:722 → 836
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd00116
      Location:89 → 375
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:106 → 128
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:131 → 186
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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