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    Map3k11 mitogen-activated protein kinase kinase kinase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309168, updated on 9-Dec-2024

    Summary

    Symbol
    Map3k11provided by RGD
    Full Name
    mitogen-activated protein kinase kinase kinase 11provided by RGD
    Primary source
    RGD:1359261
    See related
    EnsemblRapid:ENSRNOG00000020773 AllianceGenome:RGD:1359261
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mlk3; RHOE; Mlk-3
    Summary
    Enables ATP binding activity; JUN kinase kinase kinase activity; and enzyme binding activity. Involved in several processes, including JNK cascade; positive regulation of JNK cascade; and protein autophosphorylation. Predicted to be located in microtubule. Predicted to be active in centrosome and cytoplasm. Orthologous to human MAP3K11 (mitogen-activated protein kinase kinase kinase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 154.6), Kidney (RPKM 123.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Map3k11 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212404685..212417986)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202975353..202988655)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221043119..221056420)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene signal-induced proliferation-associated 1 Neighboring gene pecanex 3 Neighboring gene uncharacterized LOC102546344 Neighboring gene potassium two pore domain channel subfamily K member 7 Neighboring gene EH domain binding protein 1-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables JUN kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables JUN kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 11
    Names
    mixed lineage kinase 3
    NP_001013168.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013150.1NP_001013168.1  mitogen-activated protein kinase kinase kinase 11

      See identical proteins and their annotated locations for NP_001013168.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081952
      UniProtKB/Swiss-Prot
      Q66HA1, Q80YF1
      UniProtKB/TrEMBL
      A6HZ88
      Related
      ENSRNOP00000105161.1, ENSRNOT00000157493.1
      Conserved Domains (2) summary
      cd12059
      Location:46103
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14147
      Location:114380
      STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212404685..212417986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)