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    Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mms19provided by RGD
    Official Full Name
    MMS19 homolog, cytosolic iron-sulfur assembly componentprovided by RGD
    Primary source
    RGD:727890
    See related
    EnsemblRapid:ENSRNOG00000046769 AllianceGenome:RGD:727890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mms19l
    Summary
    Predicted to enable enzyme binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol; nucleoplasm; and spindle. Predicted to be part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 86.8), Heart (RPKM 82.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mms19 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (250706595..250743604, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (240757279..240794291, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (261191646..261229070, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene exosome component 1 Neighboring gene zinc finger DHHC-type palmitoyltransferase 16 Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin domain containing 1 Neighboring gene ankyrin repeat domain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A compilation of partial sequences of randomly selected cDNA clones from the rat incisor. Matsuki Y, et al. J Dent Res, 1995 Jan. PMID 7876422
    2. The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor. Wu X, et al. J Biol Chem, 2001 Jun 29. PMID 11279242
    3. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD, et al. Biochim Biophys Acta, 2015 Jun. PMID 25583461
    4. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Ito S, et al. Mol Cell, 2010 Aug 27. PMID 20797633
    5. Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase. Weon JL, et al. Mol Cell, 2018 Jan 4. PMID 29225034

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MMXD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MMXD complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MMS19 nucleotide excision repair protein homolog
    Names
    MMS19 cytosolic iron-sulfur assembly component
    MMS19 nucleotide excision repair homolog
    MMS19 nucleotide excision repair-like
    MMS19-like (MET18 homolog, S. cerevisiae)
    incisor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271596.1 → NP_001258525.1  MMS19 nucleotide excision repair protein homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5Y1K6, M0R6T4
      Related
      ENSRNOP00000065140.1, ENSRNOT00000075531.4
      Conserved Domains (2) summary
      pfam12460
      Location:555 → 963
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:54 → 312
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      250706595..250743604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231382.4 → XP_006231444.1  MMS19 nucleotide excision repair protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y1K6
      Conserved Domains (2) summary
      pfam12460
      Location:554 → 962
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:54 → 312
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    2. XM_039087880.2 → XP_038943808.1  MMS19 nucleotide excision repair protein homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1K6
      Conserved Domains (2) summary
      pfam12460
      Location:511 → 919
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:47 → 268
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    3. XM_039087987.2 → XP_038943915.1  MMS19 nucleotide excision repair protein homolog isoform X3

      Conserved Domains (1) summary
      pfam12460
      Location:190 → 598
      MMS19_C; RNAPII transcription regulator C-terminal

    RNA

    1. XR_005490967.2 RNA Sequence

    2. XR_010058213.1 RNA Sequence

    3. XR_005490966.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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