Slc24a4 solute carrier family 24 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc24a4provided by RGD
Official Full Name: solute carrier family 24 member 4provided by RGD
Primary source: RGD:1305926
See related: EnsemblRapid:ENSRNOG00000006729 AllianceGenome:RGD:1305926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nckx4
Summary: Predicted to enable calcium ion transmembrane transporter activity; calcium-dependent protein binding activity; and calmodulin binding activity. Predicted to be involved in several processes, including cellular response to high light intensity; cone photoresponse recovery; and monoatomic cation transmembrane transport. Predicted to act upstream of or within positive regulation of gene expression. Predicted to be located in several cellular components, including cone photoreceptor outer segment; cytoplasm; and vesicle. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A5 and pigmentation disease. Orthologous to human SLC24A4 (solute carrier family 24 member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 23.4), Lung (RPKM 22.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (127044470..127184684)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (121279590..121419811)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (126015799..126158727)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mRNA encoding NCKX3 and NCKX4 was demonstrated by RT-PCR and Northern blot in both rat mesenteric and aortic smooth muscle providing evidence for their role in mediating vascular tone.
Title: Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138594 (e-PCR)
- UniSTS:220681

UniSTS:224816 (e-PCR)
- UniSTS:224816

NoName (e-PCR)
- UniSTS:495678

BF392535 (e-PCR)
- UniSTS:243540

NoName (e-PCR)
- UniSTS:490864

D6Hmgc16 (e-PCR)
- UniSTS:530830

RH132681 (e-PCR)
- UniSTS:215964

Slc24a4 (e-PCR), detects polymorphism
- UniSTS:547029

RH143188 (e-PCR)
- UniSTS:232435

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium, potassium:sodium antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium, potassium:sodium antiporter activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amelogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to high light intensity	ISO Inferred from Sequence Orthology more info
involved_in cone photoresponse recovery	ISO Inferred from Sequence Orthology more info
involved_in detection of chemical stimulus involved in sensory perception of smell	ISO Inferred from Sequence Orthology more info
acts_upstream_of drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of olfactory nerve maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of phototransduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of eating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of response to melanocyte-stimulating hormone	ISO Inferred from Sequence Orthology more info
involved_in response to odorant	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cone photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/potassium/calcium exchanger 4

Names: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401345.2 → NP_001388274.1 sodium/potassium/calcium exchanger 4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K3S9, A0A8J8XAJ2

Related

ENSRNOP00000072760.1, ENSRNOT00000089840.3
NM_001401346.2 → NP_001388275.1 sodium/potassium/calcium exchanger 4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8J8XAJ2