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    Nup214 nucleoporin 214 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296634, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup214provided by RGD
    Official Full Name
    nucleoporin 214provided by RGD
    Primary source
    RGD:1304977
    See related
    EnsemblRapid:ENSRNOG00000023393 AllianceGenome:RGD:1304977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304977
    Summary
    Enables nuclear localization sequence binding activity. Predicted to be involved in regulation of nucleocytoplasmic transport. Predicted to act upstream of or within nucleocytoplasmic transport and regulation of cell cycle. Located in nuclear envelope. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 80.4), Spleen (RPKM 76.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nup214 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (35652841..35738323)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15255111..15340568)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (10993584..11070638) , (9227869..9236878, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene laminin subunit gamma 3 Neighboring gene allograft inflammatory factor 1-like Neighboring gene family with sequence similarity 78, member A Neighboring gene uncharacterized LOC134486353

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. Kraemer D, et al. Proc Natl Acad Sci U S A, 1994 Feb 15. PMID 8108440, Free PMC Article
    2. G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214. van Deursen J, et al. EMBO J, 1996 Oct 15. PMID 8896451, Free PMC Article
    3. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Xu L, et al. Mol Cell, 2002 Aug. PMID 12191473
    4. Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex. Bastos R, et al. J Cell Biol, 1997 Jun 2. PMID 9166401, Free PMC Article
    5. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Radu A, et al. Proc Natl Acad Sci U S A, 1995 Feb 28. PMID 7878057, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup214
    Names
    nucleoporin 214kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168559.1 → NP_001162031.1  nuclear pore complex protein Nup214

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JU39
      Conserved Domains (6) summary
      COG2319
      Location:23 → 266
      WD40; WD40 repeat [General function prediction only]
      pfam16208
      Location:1812 → 1977
      Keratin_2_head; Keratin type II head
      pfam16755
      Location:319 → 376
      NUP214; Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
      sd00039
      Location:39 → 86
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:94 → 216
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl10080
      Location:589 → 667
      RPE65; Retinal pigment epithelial membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      35652841..35738323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104750.2 → XP_038960678.1  nuclear pore complex protein Nup214 isoform X1

      UniProtKB/TrEMBL
      A6JU39
      Conserved Domains (7) summary
      PHA03247
      Location:425 → 688
      PHA03247; large tegument protein UL36; Provisional
      COG5651
      Location:1784 → 2081
      COG5651; PPE-repeat protein [Function unknown]
      sd00039
      Location:39 → 86
      7WD40; WD40 repeat [structural motif]
      pfam12894
      Location:155 → 216
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam15967
      Location:1947 → 2053
      Nucleoporin_FG2; Nucleoporin FG repeated region
      pfam18617
      Location:1913 → 1972
      Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain
      cl29593
      Location:23 → 216
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039104751.2 → XP_038960679.1  nuclear pore complex protein Nup214 isoform X2

      UniProtKB/TrEMBL
      A6JU39
      Conserved Domains (7) summary
      PHA03247
      Location:425 → 688
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:39 → 86
      7WD40; WD40 repeat [structural motif]
      pfam12894
      Location:155 → 216
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam15967
      Location:1946 → 2052
      Nucleoporin_FG2; Nucleoporin FG repeated region
      pfam18617
      Location:1912 → 1971
      Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain
      cl11081
      Location:1710 → 1954
      dermokine
      cl29593
      Location:23 → 216
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_039104752.2 → XP_038960680.1  nuclear pore complex protein Nup214 isoform X3

      UniProtKB/TrEMBL
      A6JU39, D4ACK1
      Related
      ENSRNOP00000033579.7, ENSRNOT00000037164.9
      Conserved Domains (7) summary
      PHA03247
      Location:425 → 688
      PHA03247; large tegument protein UL36; Provisional
      COG5651
      Location:1767 → 2064
      COG5651; PPE-repeat protein [Function unknown]
      sd00039
      Location:39 → 86
      7WD40; WD40 repeat [structural motif]
      pfam12894
      Location:155 → 216
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam15967
      Location:1930 → 2036
      Nucleoporin_FG2; Nucleoporin FG repeated region
      pfam18617
      Location:1896 → 1955
      Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain
      cl29593
      Location:23 → 216
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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