Rnf31 ring finger protein 31 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf31provided by RGD
Official Full Name: ring finger protein 31provided by RGD
Primary source: RGD:1305513
See related: EnsemblRapid:ENSRNOG00000019438 AllianceGenome:RGD:1305513
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including linear polyubiquitin binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within negative regulation of necroptotic process. Predicted to be located in cytoplasmic side of plasma membrane and cytosol. Predicted to be part of CD40 receptor complex and LUBAC complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RNF31 (ring finger protein 31). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 66.5), Spleen (RPKM 64.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33053450..33065285)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29083047..29095328)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34270037..34282385)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K48-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables linear polyubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of xenophagy	ISO Inferred from Sequence Orthology more info
involved_in protein linear polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein linear polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CD40 receptor complex	ISO Inferred from Sequence Orthology more info
part_of LUBAC complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF31

NP_001102338.2

EC 2.3.2.27

XP_006252062.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108868.1 → NP_001102338.2 E3 ubiquitin-protein ligase RNF31

See identical proteins and their annotated locations for NP_001102338.2

Status: PROVISIONAL

Source sequence(s)

CH474049

UniProtKB/TrEMBL

A0A8I6A2Y9, A6KH19, E9PU29

Related

ENSRNOP00000026333.5, ENSRNOT00000026333.9

Conserved Domains (7) summary

smart00647
Location:769 → 831

IBR; In Between Ring fingers

cd14325
Location:561 → 615

UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins

sd00029
Location:348 → 367

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam04981
Location:689 → 739

NMD3; NMD3 family

pfam16678
Location:473 → 617

HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase

cl00873
Location:523 → 594

PdxA; Pyridoxal phosphate biosynthetic protein PdxA

cl15262
Location:51 → 152

PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

33053450..33065285

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252000.5 → XP_006252062.1 E3 ubiquitin-protein ligase RNF31 isoform X1

UniProtKB/TrEMBL

A0A8I6A2Y9

Conserved Domains (8) summary

smart00647
Location:768 → 830

IBR; In Between Ring fingers

cd14325
Location:560 → 614

UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins

sd00029
Location:348 → 367

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam04981
Location:688 → 738

NMD3; NMD3 family

pfam14636
Location:365 → 516

FNIP_N; Folliculin-interacting protein N-terminus

pfam16678
Location:472 → 616

HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase

cl00873
Location:522 → 593

PdxA; Pyridoxal phosphate biosynthetic protein PdxA

cl15262
Location:51 → 152

PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins