Thnsl2 threonine synthase-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Thnsl2provided by RGD
Official Full Name: threonine synthase-like 2provided by RGD
Primary source: RGD:1309144
See related: EnsemblRapid:ENSRNOG00000006508 AllianceGenome:RGD:1309144
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tsh2; RGD1309144
Summary: Predicted to enable pyridoxal phosphate binding activity and serine binding activity. Predicted to be involved in 2-oxobutyrate biosynthetic process; dephosphorylation; and serine family amino acid catabolic process. Orthologous to human THNSL2 (threonine synthase like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 661.0), Liver (RPKM 101.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (104671305..104691084, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (103112974..103132122, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (98976559..98997187, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH144071 (e-PCR)
- UniSTS:233317

RH130845 (e-PCR)
- UniSTS:214129

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables serine binding	IEA Inferred from Electronic Annotation more info
enables serine binding	ISO Inferred from Sequence Orthology more info
NOT enables threonine synthase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 2-oxobutyrate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 2-oxobutyrate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 2-oxobutyrate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in serine family amino acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in serine family amino acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in serine family amino acid catabolic process	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within threonine biosynthetic process	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: threonine synthase-like 2

NP_001009658.1

EC 4.2.3.-

XP_038963237.1

EC 4.2.3.-

XP_038963240.1

EC 4.2.3.-

XP_063141844.1

EC 4.2.3.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009658.1 → NP_001009658.1 threonine synthase-like 2

See identical proteins and their annotated locations for NP_001009658.1

Status: PROVISIONAL

Source sequence(s)

BC088454

UniProtKB/Swiss-Prot

Q5M7T9

Related

ENSRNOP00000008698.6, ENSRNOT00000008698.8

Conserved Domains (1) summary

cd01560
Location:2 → 465

Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

104671305..104691084 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285774.1 → XP_063141844.1 threonine synthase-like 2 isoform X3
XM_039107312.2 → XP_038963240.1 threonine synthase-like 2 isoform X2

Conserved Domains (1) summary

cl00342
Location:2 → 349

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
XM_039107309.2 → XP_038963237.1 threonine synthase-like 2 isoform X1

UniProtKB/TrEMBL

A0A8L2Q4L2, A6IA65

Related

ENSRNOP00000102122.1, ENSRNOT00000169150.1

Conserved Domains (1) summary

cd01560
Location:2 → 464

Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...