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    Nsd2 nuclear receptor binding SET domain protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nsd2provided by RGD
    Official Full Name
    nuclear receptor binding SET domain protein 2provided by RGD
    Primary source
    RGD:1307955
    See related
    EnsemblRapid:ENSRNOG00000038140 AllianceGenome:RGD:1307955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Whsc1; RGD1565590
    Summary
    Predicted to enable chromatin binding activity; histone H3K36 trimethyltransferase activity; and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including bone development; cardiac septum morphogenesis; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in chromatin and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 155.9), Brain (RPKM 140.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsd2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81057727..81135866, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (76833179..76911304, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82119210..82196501, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene NELL2 interacting cell ontogeny regulator 1 Neighboring gene negative elongation factor complex member A Neighboring gene uncharacterized LOC134481859 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene ribosomal protein L18, pseudogene 12 Neighboring gene fibroblast growth factor receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy. Zhou XL, et al. Clin Sci (Lond), 2019 May 31. PMID 31040165
    2. Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer. Guan S, et al. J Cell Mol Med, 2021 Oct. PMID 34551195, Free PMC Article
    3. The histone methyltransferase MMSET regulates class switch recombination. Pei H, et al. J Immunol, 2013 Jan 15. PMID 23241889, Free PMC Article
    4. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nimura K, et al. Nature, 2009 Jul 9. PMID 19483677
    5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K36 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K36 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K36 trimethyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within atrial septum primum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within atrial septum secundum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within membranous septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of isotype switching to IgA isotypes ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase NSD2
    Names
    Wolf-Hirschhorn syndrome candidate 1
    probable histone-lysine N-methyltransferase NSD2
    NP_001178481.2
    XP_006251434.1
    XP_006251435.1
    XP_006251438.1
    XP_006251440.1
    XP_008768586.1
    XP_017454868.1
    XP_038948357.1
    XP_038948358.1
    XP_038948359.1
    XP_038948360.1
    XP_038948361.1
    XP_038948362.1
    XP_038948363.1
    XP_038948364.1
    XP_038948365.1
    XP_038948366.1
    XP_038948367.1
    XP_063129686.1
    XP_063129689.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191552.2 → NP_001178481.2  histone-lysine N-methyltransferase NSD2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      D4A9J4
      Related
      ENSRNOP00000021952.8, ENSRNOT00000021952.8
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      81057727..81135866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092433.2 → XP_038948361.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    2. XM_039092430.2 → XP_038948358.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    3. XM_039092436.2 → XP_038948364.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    4. XM_039092429.2 → XP_038948357.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    5. XM_039092434.2 → XP_038948362.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    6. XM_039092437.2 → XP_038948365.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    7. XM_039092431.2 → XP_038948359.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    8. XM_039092435.2 → XP_038948363.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    9. XM_039092432.2 → XP_038948360.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    10. XM_039092438.2 → XP_038948366.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    11. XM_063273619.1 → XP_063129689.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4

    12. XM_017599379.3 → XP_017454868.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    13. XM_006251378.5 → XP_006251440.1  histone-lysine N-methyltransferase NSD2 isoform X1

      See identical proteins and their annotated locations for XP_006251440.1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    14. XM_063273616.1 → XP_063129686.1  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      D4A9J4

    15. XM_008770364.4 → XP_008768586.1  histone-lysine N-methyltransferase NSD2 isoform X1

      See identical proteins and their annotated locations for XP_008768586.1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    16. XM_006251373.5 → XP_006251435.1  histone-lysine N-methyltransferase NSD2 isoform X1

      See identical proteins and their annotated locations for XP_006251435.1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    17. XM_006251376.5 → XP_006251438.1  histone-lysine N-methyltransferase NSD2 isoform X1

      See identical proteins and their annotated locations for XP_006251438.1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    18. XM_006251372.5 → XP_006251434.1  histone-lysine N-methyltransferase NSD2 isoform X1

      See identical proteins and their annotated locations for XP_006251434.1

      UniProtKB/TrEMBL
      D4A9J4
      Conserved Domains (11) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:878 → 972
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1012 → 1062
      AWS; associated with SET domains
      COG5034
      Location:546 → 710
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15648
      Location:669 → 711
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15654
      Location:763 → 816
      PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
      cd15660
      Location:1241 → 1283
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1062 → 1203
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17982
      Location:1282 → 1327
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:716 → 762
      PHD_SF; PHD finger superfamily

    19. XM_039092439.2 → XP_038948367.1  histone-lysine N-methyltransferase NSD2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZU53
      Related
      ENSRNOP00000082542.1, ENSRNOT00000106566.2
      Conserved Domains (2) summary
      cd05837
      Location:218 → 337
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd00084
      Location:460 → 505
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    Nucleotide Protein Strain
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