Cyb561 cytochrome b-561 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyb561provided by RGD
Official Full Name: cytochrome b-561provided by RGD
Primary source: RGD:1310987
See related: EnsemblRapid:ENSRNOG00000007433 AllianceGenome:RGD:1310987
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transmembrane monodehydroascorbate reductase activity. Predicted to be involved in ascorbate homeostasis and intracellular iron ion homeostasis. Predicted to be located in chromaffin granule membrane. Predicted to be active in lysosomal membrane. Orthologous to human CYB561 (cytochrome b561). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 226.5), Lung (RPKM 145.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (91377866..91388548, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (90878052..90888734, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94136993..94147567, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137647 (e-PCR)
- UniSTS:219734

BF409851 (e-PCR)
- UniSTS:249004

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane monodehydroascorbate reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ascorbate homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromaffin granule membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome b-561

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107056.3 → NP_001100526.1 cytochrome b-561

See identical proteins and their annotated locations for NP_001100526.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8J8YNX3, B5DFI2, D3ZV03

Conserved Domains (1) summary

cl23723
Location:43 → 184

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

91377866..91388548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768357.4 → XP_008766579.1 cytochrome b-561 isoform X2

See identical proteins and their annotated locations for XP_008766579.1

UniProtKB/TrEMBL

A0A8J8YNX3, B5DFI2, D3ZV03

Conserved Domains (1) summary

cl23723
Location:43 → 184

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_063269200.1 → XP_063125270.1 cytochrome b-561 isoform X2

UniProtKB/TrEMBL

A0A8J8YNX3, B5DFI2, D3ZV03
XM_063269199.1 → XP_063125269.1 cytochrome b-561 isoform X2

UniProtKB/TrEMBL

A0A8J8YNX3, B5DFI2, D3ZV03
XM_039086163.2 → XP_038942091.2 cytochrome b-561 isoform X1

UniProtKB/TrEMBL

A0A8J8YNX3

Related

ENSRNOP00000009778.7, ENSRNOT00000009778.10