Cidec cell death-inducing DFFA-like effector c [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cidecprovided by MGI
Official Full Name: cell death-inducing DFFA-like effector cprovided by MGI
Primary source: MGI:MGI:95585
See related: Ensembl:ENSMUSG00000030278 AllianceGenome:MGI:95585
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fsp27; CIDE-3
Summary: Enables lipid transfer activity; molecular condensate scaffold activity; and phospholipid binding activity. Involved in lipid droplet fusion; lipid storage; and negative regulation of lipid metabolic process. Is active in lipid droplet. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5. Orthologous to human CIDEC (cell death inducing DFFA like effector c). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 1173.4), genital fat pad adult (RPKM 661.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.76 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (113401595..113412721, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (113424634..113435760, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Small Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid.
Title: Small Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid.
Synergistic regulation of hepatic Fsp27b expression by HNF4alpha and CREBH.
Title: Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH.
Fat-specific protein 27b is regulated by hepatic peroxisome proliferator-activated receptor gamma in hepatic steatosis.
Title: Fat-specific protein 27b is regulated by hepatic peroxisome proliferator-activated receptor γ in hepatic steatosis.
Eicosapentaenoic acid-enriched phospholipids suppressed lipid accumulation by specific inhibition of lipid droplet-associated protein FSP27 in mice.
Title: Eicosapentaenoic acid-enriched phospholipids suppressed lipid accumulation by specific inhibition of lipid droplet-associated protein FSP27 in mice.
When Pgc1a-deficient mice were used, the sex differences in Cidec/Fsp27beta expression disappeared
Title: Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet.
Growth hormone-induced lipolysis is secondary to its reduction in the expression of FSP27.
Title: Growth hormone controls lipolysis by regulation of FSP27 expression.
LXRalpha positively regulates Fsp27a and Fsp27b expression.
Title: Fat-specific protein 27 is a novel target gene of liver X receptor α.
a CIDEC domain that regulates LD fusion activity
Title: Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids.
the role of gp78 and cidec in hepatic steatosis, were investigated.
Title: Role of glycoprotein 78 and cidec in hepatic steatosis.
The current study demonstrated that insulin represses fasting-induced Fsp27 expression in the liver. The Fsp27 decreased by insulin is likely to cause the lower fat accumulation in liver.
Title: Insulin Represses Fasting-Induced Expression of Hepatic Fat-Specific Protein 27.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fsp27 (e-PCR), detects polymorphism
- UniSTS:143143

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid droplet fusion	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet organization	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
is_active_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipid transferase CIDEC

Names: CIDE-3alpha; cell death activator CIDE-3; cell death-inducing DFFA-like effector protein C; fat specific gene 27; fat-specific protein FSP27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301295.1 → NP_001288224.1 lipid transferase CIDEC isoform 1

See identical proteins and their annotated locations for NP_001288224.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC153910

Consensus CDS

CCDS20418.1

UniProtKB/Swiss-Prot

P56198, Q499X5, Q8BNV7

Related

ENSMUSP00000108712.2, ENSMUST00000113089.8

Conserved Domains (1) summary

cl02541
Location:41 → 120

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
NM_001372264.1 → NP_001359193.1 lipid transferase CIDEC isoform 2

Status: VALIDATED

Source sequence(s)

AC153910

Consensus CDS

CCDS90100.1

UniProtKB/TrEMBL

E9QMZ0

Related

ENSMUSP00000108714.2, ENSMUST00000113091.8

Conserved Domains (1) summary

cl02541
Location:51 → 130

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
NM_178373.4 → NP_848460.1 lipid transferase CIDEC isoform 1

See identical proteins and their annotated locations for NP_848460.1

Status: VALIDATED

Source sequence(s)

AC153910, AK080133

Consensus CDS

CCDS20418.1

UniProtKB/Swiss-Prot

P56198, Q499X5, Q8BNV7

Related

ENSMUSP00000032416.5, ENSMUST00000032416.11

Conserved Domains (1) summary

cl02541
Location:41 → 120

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...