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    RPL39 ribosomal 60S subunit protein L39 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL39
    Official Full Name
    ribosomal 60S subunit protein L39
    Primary source
    SGD:S000003725
    Locus tag
    YJL189W
    See related
    AllianceGenome:SGD:S000003725; FungiDB:YJL189W; VEuPathDB:YJL189W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPL46; SPB2
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPL39 (ribosomal protein L39); RPL39L (ribosomal protein L39 like); and RPL39P5 (ribosomal protein L39 pseudogene 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL39 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    2
    Sequence:
    Chromosome: X; NC_001142.9 (75933..76474)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S14B Neighboring gene ribosomal 40S subunit protein S22A Neighboring gene tyrosine protein kinase SWE1 Neighboring gene alpha-1,2-mannosyltransferase MNN5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation. Micic J, et al. Nucleic Acids Res, 2022 Jun 24. PMID 35639884, Free PMC Article
    2. Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46. Sachs AB, et al. Science, 1990 Mar 2. PMID 2408148
    3. The divergently transcribed genes encoding yeast ribosomal proteins L46 and S24 are activated by shared RPG-boxes. Kraakman LS, et al. Nucleic Acids Res, 1989 Dec 11. PMID 2602141, Free PMC Article
    4. The genes for yeast ribosomal proteins S24 and L46 are adjacent and divergently transcribed. Leer RJ, et al. Nucleic Acids Res, 1985 Feb 11. PMID 4000930, Free PMC Article
    5. Analysis of an essential requirement for the poly(A) binding protein function using cross-species complementation. Chekanova JA, et al. Curr Biol, 2001 Aug 7. PMID 11516954

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation.
      Title: Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation.
    2. Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39
      Title: Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39 of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L39
    NP_012346.1
    • Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      75933..76474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181622.1 → NP_012346.1  TPA: ribosomal 60S subunit protein L39 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW02, P04650
      UniProtKB/TrEMBL
      A6ZQE7, B3LPT8, C8ZB30, G2WGI8
      Conserved Domains (1) summary
      COG2167
      Location:1 → 51
      RPL39; Ribosomal protein L39E [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04650.3

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