TNK1 tyrosine kinase non receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNK1provided by HGNC
Official Full Name: tyrosine kinase non receptor 1provided by HGNC
Primary source: HGNC:HGNC:11940
See related: Ensembl:ENSG00000174292 MIM:608076; AllianceGenome:HGNC:11940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KOS1
Summary: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression: Ubiquitous expression in stomach (RPKM 6.3), duodenum (RPKM 4.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (7380047..7389742)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (7285126..7293784)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (7284408..7293061)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
Title: Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity.
Title: The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity.
Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer's Disease.
Title: Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer's Disease.
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
Title: TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock.
Title: Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock.
TNK1 was found to be deregulated in the gut in murine and porcine trauma models and human inflammatory bowel disease. Thus, TNK1 might be a target during MODS to prevent damage in several organs, notably the gut.
Title: Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
the Single nucleotide polymorphisms rs11136000 of CLU, rs541458 of PICALM, and rs1554948 of TNK1 according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients, were studied.
Title: Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease.
The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions.
Title: Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.
The application of functional genomics by using high-throughput-RNAi screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells.
Title: High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of tyrosine kinase, non-receptor, 1 (TNK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93312 (e-PCR)
- UniSTS:85374

RH79604 (e-PCR)
- UniSTS:87219

RH17416 (e-PCR)
- UniSTS:25270

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: non-receptor tyrosine-protein kinase TNK1

Names: CD38 negative kinase 1

NP_001238831.1

EC 2.7.10.2

NP_003976.2

EC 2.7.10.2

XP_011522347.1

EC 2.7.10.2

XP_011522348.1

EC 2.7.10.2

XP_011522349.1

EC 2.7.10.2

XP_011522350.1

EC 2.7.10.2

XP_054173634.1

EC 2.7.10.2

XP_054173635.1

EC 2.7.10.2

XP_054173636.1

EC 2.7.10.2

XP_054188002.1

EC 2.7.10.2

XP_054188003.1

EC 2.7.10.2

XP_054188004.1

EC 2.7.10.2

XP_054188005.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001251902.3 → NP_001238831.1 non-receptor tyrosine-protein kinase TNK1 isoform 1

See identical proteins and their annotated locations for NP_001238831.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC113189

Consensus CDS

CCDS58510.1

UniProtKB/Swiss-Prot

O95364, Q13470, Q8IYI4

Related

ENSP00000459799.1, ENST00000576812.5

Conserved Domains (6) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00221
Location:119 → 377

STYKc; Protein kinase; unclassified specificity

smart00326
Location:385 → 441

SH3; Src homology 3 domains

cd14328
Location:624 → 663

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cl21453
Location:120 → 379

PKc_like; Protein Kinases, catalytic domain

cl21463
Location:594 → 637

UBA_like_SF; UBA domain-like superfamily
NM_003985.6 → NP_003976.2 non-receptor tyrosine-protein kinase TNK1 isoform 2

See identical proteins and their annotated locations for NP_003976.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 5 aa protein segment compared to isoform 1.

Source sequence(s)

AC113189

Consensus CDS

CCDS45602.1

UniProtKB/Swiss-Prot

Q13470

Related

ENSP00000509611.1, ENST00000688331.1

Conserved Domains (6) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00221
Location:119 → 377

STYKc; Protein kinase; unclassified specificity

cd14328
Location:619 → 658

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cl17036
Location:396 → 435

SH3; Src Homology 3 domain superfamily

cl21453
Location:120 → 379

PKc_like; Protein Kinases, catalytic domain

cl21463
Location:589 → 632

UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

7380047..7389742

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011524045.3 → XP_011522347.1 non-receptor tyrosine-protein kinase TNK1 isoform X1

See identical proteins and their annotated locations for XP_011522347.1

UniProtKB/Swiss-Prot

Q13470

Conserved Domains (6) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00221
Location:119 → 377

STYKc; Protein kinase; unclassified specificity

cd14328
Location:619 → 658

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cl17036
Location:396 → 435

SH3; Src Homology 3 domain superfamily

cl21453
Location:120 → 379

PKc_like; Protein Kinases, catalytic domain

cl21463
Location:589 → 632

UBA_like_SF; UBA domain-like superfamily
XM_011524047.4 → XP_011522349.1 non-receptor tyrosine-protein kinase TNK1 isoform X3

UniProtKB/TrEMBL

G9BXQ3

Conserved Domains (4) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00221
Location:119 → 377

STYKc; Protein kinase; unclassified specificity

cl17036
Location:396 → 435

SH3; Src Homology 3 domain superfamily

cl21453
Location:120 → 379

PKc_like; Protein Kinases, catalytic domain
XM_011524046.4 → XP_011522348.1 non-receptor tyrosine-protein kinase TNK1 isoform X2

Conserved Domains (6) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00221
Location:119 → 377

STYKc; Protein kinase; unclassified specificity

cd14328
Location:617 → 656

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cl17036
Location:396 → 435

SH3; Src Homology 3 domain superfamily

cl21453
Location:120 → 379

PKc_like; Protein Kinases, catalytic domain

cl21463
Location:587 → 630

UBA_like_SF; UBA domain-like superfamily
XM_011524048.2 → XP_011522350.1 non-receptor tyrosine-protein kinase TNK1 isoform X4

Conserved Domains (4) summary

cd14328
Location:462 → 501

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cl17036
Location:239 → 278

SH3; Src Homology 3 domain superfamily

cl21453
Location:7 → 222

PKc_like; Protein Kinases, catalytic domain

cl21463
Location:432 → 475

UBA_like_SF; UBA domain-like superfamily

Reference GRCh38.p14 PATCHES

Genomic

NW_016107299.1 Reference GRCh38.p14 PATCHES

Range

504..10199

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054332027.1 → XP_054188002.1 non-receptor tyrosine-protein kinase TNK1 isoform X1
XM_054332029.1 → XP_054188004.1 non-receptor tyrosine-protein kinase TNK1 isoform X3

UniProtKB/TrEMBL

G9BXQ3
XM_054332028.1 → XP_054188003.1 non-receptor tyrosine-protein kinase TNK1 isoform X2
XM_054332030.1 → XP_054188005.1 non-receptor tyrosine-protein kinase TNK1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

7285126..7293784

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054317660.1 → XP_054173635.1 non-receptor tyrosine-protein kinase TNK1 isoform X3

UniProtKB/TrEMBL

G9BXQ3
XM_054317659.1 → XP_054173634.1 non-receptor tyrosine-protein kinase TNK1 isoform X2
XM_054317661.1 → XP_054173636.1 non-receptor tyrosine-protein kinase TNK1 isoform X4