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    CPEB2 cytoplasmic polyadenylation element binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 132864, updated on 27-Nov-2024

    Summary

    Official Symbol
    CPEB2provided by HGNC
    Official Full Name
    cytoplasmic polyadenylation element binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:21745
    See related
    Ensembl:ENSG00000137449 MIM:610605; AllianceGenome:HGNC:21745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPEB-2; CPE-BP2; hCPEB-2
    Summary
    The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 12.0), skin (RPKM 7.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CPEB2 in Genome Data Viewer
    Location:
    4p15.32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (15002481..15070151)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (14984261..15051932)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15004105..15071775)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 504 Neighboring gene uncharacterized LOC105374496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:14667012-14667571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21331 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:14857565-14858764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21334 Neighboring gene uncharacterized LOC105374498 Neighboring gene CPEB2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15294 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:15005985-15006551 Neighboring gene C1QTNF7 antisense RNA 1 Neighboring gene uncharacterized LOC124900673 Neighboring gene RN7SK pseudogene 170

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119575, MGC119576, MGC119577

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR AU-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA regulatory element binding translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA regulatory element binding translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal large subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation factor activity, RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytoplasmic translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytoplasmic polyadenylation element-binding protein 2
    Names
    CPE-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177381.2 → NP_001170852.1  cytoplasmic polyadenylation element-binding protein 2 isoform C

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, compared to variant D. The resulting isoform (C) differs at an internal region, compared to isoform D.
      Source sequence(s)
      AC098829, AC105289, BC103939
      Consensus CDS
      CCDS56326.1
      UniProtKB/Swiss-Prot
      Q7Z5Q1
      Related
      ENSP00000414270.2, ENST00000442003.6
      Conserved Domains (4) summary
      COG0724
      Location:737 → 912
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:750 → 841
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:858 → 938
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:933 → 994
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    2. NM_001177382.2 → NP_001170853.1  cytoplasmic polyadenylation element-binding protein 2 isoform D

      Status: REVIEWED

      Description
      Transcript Variant: This variant (D) represents the longest transcript and encodes the longest isoform (D).
      Source sequence(s)
      AC098829, AC105289, BC103942
      Consensus CDS
      CCDS56325.1
      UniProtKB/Swiss-Prot
      Q7Z5Q1
      Related
      ENSP00000443985.1, ENST00000538197.7
      Conserved Domains (4) summary
      COG0724
      Location:764 → 939
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:777 → 868
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:885 → 965
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:960 → 1021
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    3. NM_001177383.2 → NP_001170854.1  cytoplasmic polyadenylation element-binding protein 2 isoform E

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E) lacks an alternate in-frame exon in the central coding region, compared to variant D. The resulting isoform (E) lacks an internal segment, compared to isoform D.
      Source sequence(s)
      AC098829, AC105289, BC103941
      Consensus CDS
      CCDS93479.1
      UniProtKB/TrEMBL
      A0A5K1VW71
      Related
      ENSP00000371832.4, ENST00000382395.8
      Conserved Domains (4) summary
      COG0724
      Location:734 → 909
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:747 → 838
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:855 → 935
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:930 → 991
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    4. NM_001177384.2 → NP_001170855.1  cytoplasmic polyadenylation element-binding protein 2 isoform F

      Status: REVIEWED

      Description
      Transcript Variant: This variant (F) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the central coding region, compared to variant D. The resulting isoform (F) differs at two internal regions, compared to isoform D.
      Source sequence(s)
      AC098829, AC105289, BC105925
      Consensus CDS
      CCDS93480.1
      UniProtKB/TrEMBL
      A0A5K1VW79
      Related
      ENSP00000371838.4, ENST00000382401.8
      Conserved Domains (4) summary
      COG0724
      Location:729 → 904
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:742 → 833
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:850 → 930
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:925 → 986
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    5. NM_182485.3 → NP_872291.2  cytoplasmic polyadenylation element-binding protein 2 isoform B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) lacks two alternate in-frame exons in the central coding region, compared to variant D. The resulting isoform (B) lacks two internal segments, compared to isoform D.
      Source sequence(s)
      AC098829, AC105289, AY247744
      UniProtKB/TrEMBL
      A0A5K1VW93
      Related
      ENSP00000424084.2, ENST00000507071.6
      Conserved Domains (4) summary
      COG0724
      Location:756 → 931
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:769 → 860
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:877 → 957
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:952 → 1013
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    6. NM_182646.3 → NP_872587.2  cytoplasmic polyadenylation element-binding protein 2 isoform A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) lacks an alternate in-frame exon in the central coding region, compared to variant D. The resulting isoform (A) lacks an internal segment, compared to isoform D.
      Source sequence(s)
      AC098829, AC105289, AY255519
      UniProtKB/TrEMBL
      A0A5K1VW61
      Related
      ENSP00000334058.4, ENST00000345451.8
      Conserved Domains (4) summary
      COG0724
      Location:726 → 901
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:739 → 830
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:847 → 927
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:922 → 983
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      15002481..15070151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005248135.4 → XP_005248192.2  cytoplasmic polyadenylation element-binding protein 2 isoform X1

      Conserved Domains (4) summary
      COG0724
      Location:767 → 942
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:780 → 871
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:888 → 968
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:963 → 1024
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    2. XM_011513777.4 → XP_011512079.1  cytoplasmic polyadenylation element-binding protein 2 isoform X2

      Conserved Domains (4) summary
      COG0724
      Location:759 → 934
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:772 → 863
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:880 → 960
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:955 → 1016
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    3. XM_011513778.4 → XP_011512080.1  cytoplasmic polyadenylation element-binding protein 2 isoform X3

    4. XM_011513779.3 → XP_011512081.1  cytoplasmic polyadenylation element-binding protein 2 isoform X4

    5. XM_017007734.3 → XP_016863223.1  cytoplasmic polyadenylation element-binding protein 2 isoform X5

      Conserved Domains (3) summary
      pfam16366
      Location:389 → 450
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      cd12724
      Location:206 → 297
      RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:314 → 394
      RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    6. XM_017007733.2 → XP_016863222.1  cytoplasmic polyadenylation element-binding protein 2 isoform X5

      Conserved Domains (3) summary
      pfam16366
      Location:389 → 450
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      cd12724
      Location:206 → 297
      RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:314 → 394
      RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    7. XM_047449609.1 → XP_047305565.1  cytoplasmic polyadenylation element-binding protein 2 isoform X6

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_013171799.1 Reference GRCh38.p14 PATCHES

      Range
      74375..89176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      14984261..15051932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348925.1 → XP_054204900.1  cytoplasmic polyadenylation element-binding protein 2 isoform X1

    2. XM_054348926.1 → XP_054204901.1  cytoplasmic polyadenylation element-binding protein 2 isoform X2

    3. XM_054348927.1 → XP_054204902.1  cytoplasmic polyadenylation element-binding protein 2 isoform X3

    4. XM_054348928.1 → XP_054204903.1  cytoplasmic polyadenylation element-binding protein 2 isoform X4

    5. XM_054348929.1 → XP_054204904.1  cytoplasmic polyadenylation element-binding protein 2 isoform X5

    6. XM_054348930.1 → XP_054204905.1  cytoplasmic polyadenylation element-binding protein 2 isoform X5

    7. XM_054348931.1 → XP_054204906.1  cytoplasmic polyadenylation element-binding protein 2 isoform X6