SWE1 tyrosine protein kinase SWE1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SWE1
Official Full Name: tyrosine protein kinase SWE1
Primary source: SGD:S000003723
Locus tag: YJL187C
See related: AllianceGenome:SGD:S000003723; FungiDB:YJL187C; VEuPathDB:YJL187C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: WEE1
Summary: Enables protein tyrosine kinase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; positive regulation of sphingolipid biosynthetic process; and regulation of cell cycle process. Located in cellular bud neck and nucleus. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SWE1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (76803..79262, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.
Title: Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.
Here, we show that Rts1 is required for the proportional relationship between cell size and growth rate during mitosis. Moreover, nutrients and Rts1 influence the duration and extent of growth in mitosis via Wee1 and Pds1/securin, two conserved regulators of mitotic progression.
Title: A Conserved PP2A Regulatory Subunit Enforces Proportional Relationships Between Cell Size and Growth Rate.
Swe1 and the Polo-like kinase Cdc5 control the balance between phosphorylated and unphosphorylated forms of Mih1, which is, in turn, important for mitotic spindle elongation.
Title: Swe1 and Mih1 regulate mitotic spindle dynamics in budding yeast via Bik1.
Moreover, the authors show that high levels of histones promote Swe1(WEE1) stabilisation thereby triggering the phosphorylation and inhibition of Cdc28(CDK1) through a mechanism different of the canonical DNA damage response.
Title: High levels of histones promote whole-genome-duplications and trigger a Swe1(WEE1)-dependent phosphorylation of Cdc28(CDK1).
strict temporal regulation of M-phase cyclin-dependent kinase (CDK; M-CDK) is important for polarity establishment and morphogenesis. Cells with premature M-CDK activity caused by loss of checkpoint kinase Swe1 failed to polarize and underwent anaphase without budding. Mutants with increased Swe1-dependent M-CDK inhibition showed additional or more penetrant phenotypes in RTG than mitosis
Title: Prolonged cyclin-dependent kinase inhibition results in septin perturbations during return to growth and mitosis.
Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation.
Title: Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation.
Swe1 kinase perceives alterations in sphingolipid (SL) homeostasis, activates SL synthesis, and may thus represent the missing regulatory link that controls the SL rheostat during the cell cycle
Title: Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1.
propose a model by which TG-derived sphingolipids are required to activate the protein phosphatase 2A (PP2A(Cdc55)) to attenuate Swe1 phosphorylation
Title: Morphogenesis checkpoint kinase Swe1 is the executor of lipolysis-dependent cell-cycle progression.
Swe1 regulation by Cdc14 allows proper coordination of spindle elongation with mitotic progression.
Title: Budding yeast Swe1 is involved in the control of mitotic spindle elongation and is regulated by Cdc14 phosphatase during mitosis.
Transition from meiotic prophase to mitosis requires modulation of Cdk1 activity to coordinate cell-cycle events. Swe1 prevents formation of multinucleate cells by restraining M phase CDK activity to allow bud formation prior to nuclear division.
Title: Cdk1 modulation ensures the coordination of cell-cycle events during the switch from meiotic prophase to mitosis.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic morphogenesis checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic morphogenesis checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic spindle pole body separation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitotic spindle pole body separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sphingolipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in re-entry into mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell size	HMP more info	PubMed
involved_in regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine protein kinase SWE1

NP_012348.1

EC 2.7.11.1

Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingolipid biosynthesis via Orm2p; phosphorylates a tyrosine residue in the N-terminus of Hsp90 in a cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

76803..79262 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181620.1 → NP_012348.1 TPA: tyrosine protein kinase SWE1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012348.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW03, P32944

UniProtKB/TrEMBL

B5VL03, G2WGI9

Conserved Domains (1) summary

cd14052
Location:443 → 791

PTKc_Wee1_fungi; Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins