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    Ajuba ajuba LIM protein [ Mus musculus (house mouse) ]

    Gene ID: 16475, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ajubaprovided by MGI
    Official Full Name
    ajuba LIM proteinprovided by MGI
    Primary source
    MGI:MGI:1341886
    See related
    Ensembl:ENSMUSG00000022178 AllianceGenome:MGI:1341886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jub
    Summary
    Enables several functions, including actin filament binding activity; alpha-catenin binding activity; and transcription corepressor activity. Involved in positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; focal adhesion assembly; and regulation of kinase activity. Located in several cellular components, including cytosol; focal adhesion; and lamellipodium. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and tooth. Orthologous to human AJUBA (ajuba LIM protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 26.2), ovary adult (RPKM 18.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Ajuba in Genome Data Viewer
    Location:
    14 C2; 14 27.84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54804926..54815118, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54567469..54577661, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53858 Neighboring gene HAUS augmin-like complex, subunit 4 Neighboring gene STARR-seq mESC enhancer starr_36740 Neighboring gene STARR-seq mESC enhancer starr_36741 Neighboring gene STARR-positive B cell enhancer ABC_E7313 Neighboring gene RIKEN cDNA 4931414P19 gene Neighboring gene U6 small nuclear RNA, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_36743 Neighboring gene STARR-positive B cell enhancer ABC_E7314

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding PubMed 
    enables alpha-catenin binding PubMed 
    enables alpha-catenin binding  
    enables chromatin binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein kinase activator activity PubMed 
    enables transcription corepressor activity  
    enables transcription corepressor activity PubMed 
    enables transcription corepressor activity PubMed 
    enables transcription corepressor activity  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PubMed 
    involved_in cytoskeleton organization  
    acts_upstream_of_or_within focal adhesion assembly PubMed 
    acts_upstream_of_or_within glycerophospholipid biosynthetic process PubMed 
    acts_upstream_of_or_within lamellipodium assembly PubMed 
    involved_in miRNA-mediated gene silencing by inhibition of translation  
    involved_in miRNA-mediated gene silencing by inhibition of translation  
    acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing  
    involved_in negative regulation of hippo signaling  
    involved_in negative regulation of hippo signaling  
    involved_in negative regulation of hippo signaling  
    acts_upstream_of_or_within negative regulation of kinase activity PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of MAP kinase activity PubMed 
    acts_upstream_of_or_within positive regulation of biosynthetic process PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of kinase activity PubMed 
    acts_upstream_of_or_within positive regulation of protein-containing complex assembly  
    acts_upstream_of_or_within protein localization PubMed 
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of GTPase activity PubMed 
    acts_upstream_of_or_within regulation of cell migration PubMed 
    acts_upstream_of_or_within regulation of cell migration PubMed 
    involved_in regulation of cellular response to hypoxia  
    involved_in regulation of cellular response to hypoxia  
    involved_in response to hypoxia  
    involved_in response to hypoxia  
    involved_in response to hypoxia  
    acts_upstream_of_or_within wound healing, spreading of epidermal cells PubMed 
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    is_active_in P-body  
    located_in P-body  
    is_active_in adherens junction  
    located_in cell-cell junction  
    located_in centrosome  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in focal adhesion PubMed 
    located_in lamellipodium PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in plasma membrane  
    part_of transcription regulator complex  
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    LIM domain-containing protein ajuba
    Names
    protein ajuba

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010590.5NP_034720.2  LIM domain-containing protein ajuba

      See identical proteins and their annotated locations for NP_034720.2

      Status: VALIDATED

      Source sequence(s)
      AC164433
      Consensus CDS
      CCDS27093.1
      UniProtKB/Swiss-Prot
      P97472, Q91XC0
      Related
      ENSMUSP00000056977.9, ENSMUST00000054487.10
      Conserved Domains (3) summary
      cd09352
      Location:347400
      LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins
      cd09355
      Location:412464
      LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins
      cd09438
      Location:472533
      LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54804926..54815118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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