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    Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15360, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hmgcs2provided by MGI
    Official Full Name
    3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2provided by MGI
    Primary source
    MGI:MGI:101939
    See related
    Ensembl:ENSMUSG00000027875 AllianceGenome:MGI:101939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mHS; 1300002P16
    Summary
    Enables hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; and ketone body biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; facial bone primordium; nervous system; and reproductive system. Used to study HMG-CoA synthase 2 deficiency. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 447.3), liver adult (RPKM 391.9) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hmgcs2 in Genome Data Viewer
    Location:
    3 F2.2; 3 42.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98187747..98218054)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98280431..98310738)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40104 Neighboring gene regenerating islet-derived family, member 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:98084906-98085107 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:98085228-98085429 Neighboring gene 3-phosphoglycerate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E4565 Neighboring gene STARR-positive B cell enhancer ABC_E11203 Neighboring gene STARR-positive B cell enhancer ABC_E7932 Neighboring gene predicted gene, 31420

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process  
    involved_in acetyl-CoA metabolic process  
    involved_in acetyl-CoA metabolic process  
    involved_in adipose tissue development  
    involved_in cellular response to amino acid stimulus  
    involved_in cellular response to fatty acid  
    involved_in cellular response to glucocorticoid stimulus  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to lipopolysaccharide  
    involved_in cholesterol biosynthetic process  
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway  
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway  
    involved_in ketone body biosynthetic process  
    involved_in ketone body biosynthetic process  
    involved_in kidney development  
    involved_in liver development  
    involved_in lung development  
    involved_in midgut development  
    involved_in multicellular organismal response to stress  
    involved_in response to cAMP  
    involved_in response to ethanol  
    involved_in response to glucagon  
    involved_in response to growth hormone  
    involved_in response to linoleic acid  
    involved_in response to metal ion  
    involved_in response to monosaccharide  
    involved_in response to nutrient  
    involved_in response to prostaglandin F  
    involved_in response to starvation  
    involved_in response to temperature stimulus  
    involved_in response to testosterone  
    involved_in response to triglyceride  
    involved_in response to xenobiotic stimulus  
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial matrix  
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  

    General protein information

    Preferred Names
    hydroxymethylglutaryl-CoA synthase, mitochondrial
    Names
    3-hydroxy-3-methylglutaryl coenzyme A synthase
    HMG-CoA synthase
    NP_032282.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008256.4NP_032282.2  hydroxymethylglutaryl-CoA synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_032282.2

      Status: VALIDATED

      Source sequence(s)
      AC121771, AC147476, AK004865
      Consensus CDS
      CCDS17662.1
      UniProtKB/Swiss-Prot
      P54869, Q64740, Q9DBK1, Q9DBM4
      UniProtKB/TrEMBL
      Q8N7N8
      Related
      ENSMUSP00000088249.3, ENSMUST00000090746.3
      Conserved Domains (3) summary
      TIGR01833
      Location:50505
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam01154
      Location:53223
      HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
      pfam08540
      Location:224505
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      98187747..98218054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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