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    Trip12 thyroid hormone receptor interactor 12 [ Mus musculus (house mouse) ]

    Gene ID: 14897, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trip12provided by MGI
    Official Full Name
    thyroid hormone receptor interactor 12provided by MGI
    Primary source
    MGI:MGI:1309481
    See related
    Ensembl:ENSMUSG00000026219 AllianceGenome:MGI:1309481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtl6; TRIP-12; 1110036I07Rik; 6720416K24Rik
    Summary
    Predicted to enable nuclear thyroid hormone receptor binding activity and ubiquitin protein ligase activity. Involved in regulation of embryonic development. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in several structures, including brain and genitourinary system. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 27.8), placenta adult (RPKM 25.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trip12 in Genome Data Viewer
    Location:
    1 C5; 1 43.42 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (84698910..84818285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (84721189..84850004, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene delta/notch-like EGF repeat containing Neighboring gene STARR-seq mESC enhancer starr_01515 Neighboring gene predicted gene, 57795 Neighboring gene microRNA 5126 Neighboring gene predicted gene, 51637 Neighboring gene STARR-seq mESC enhancer starr_01519 Neighboring gene STARR-seq mESC enhancer starr_01525 Neighboring gene F-box protein 36 Neighboring gene STARR-seq mESC enhancer starr_01531 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 14 Neighboring gene predicted gene, 39669 Neighboring gene predicted pseudogene 15433

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12. Keyan KS, et al. Cell Death Dis, 2023 Oct 20. PMID 37863914, Free PMC Article
    2. Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Chen D, et al. Mol Cell, 2013 Jul 11. PMID 23747016, Free PMC Article
    3. Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells. An CI, et al. Skelet Muscle, 2013 May 10. PMID 23663701, Free PMC Article
    4. The E3 ubiquitin ligase TRIP12 is required for pancreatic acinar cell plasticity and pancreatic carcinogenesis. Brunet M, et al. J Pathol, 2024 Aug. PMID 38924548
    5. The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis. Kajiro M, et al. PLoS One, 2011. PMID 22028794, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Control of TGFbeta signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12.
      Title: Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12.
    2. Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.
      Title: Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.
    3. data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting p19(Arf) protein stability and tumour suppression
      Title: TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.
    4. Trip12 is involved in global gene expression and plays an important role in mouse development.
      Title: The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31615

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heterochromatin boundary formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterochromatin boundary formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIP12
    Names
    HECT-type E3 ubiquitin transferase TRIP12
    TR-interacting protein 12
    gene trap locus 6
    thyroid receptor interactor TRIP12
    thyroid receptor-interacting protein 12
    NP_598736.4
    XP_006496472.1
    XP_006496477.1
    XP_006496479.1
    XP_006496485.1
    XP_006496490.1
    XP_006496492.1
    XP_011236956.1
    XP_011236957.1
    XP_011236959.1
    XP_011236960.1
    XP_011236961.1
    XP_011236963.1
    XP_011236964.1
    XP_011236965.1
    XP_011236966.1
    XP_011236968.1
    XP_011236969.1
    XP_011236970.1
    XP_011236971.1
    XP_011236972.1
    XP_011236975.1
    XP_017172116.1
    XP_017172162.1
    XP_030104755.1
    XP_030104782.1
    XP_030104802.1
    XP_030104858.1
    XP_030104872.1
    XP_030104920.1
    XP_030105028.1
    XP_030105040.1
    XP_030105055.1
    XP_030105107.1
    XP_030105119.1
    XP_030105145.1
    XP_030105170.1
    XP_030105185.1
    XP_036016722.1
    XP_036016773.1
    XP_036016798.1
    XP_036016802.1
    XP_036016854.1
    XP_036016870.1
    XP_036016899.1
    XP_036017009.1
    XP_036017145.1
    XP_036017160.1
    XP_036017182.1
    XP_036017235.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133975.4 → NP_598736.4  E3 ubiquitin-protein ligase TRIP12

      See identical proteins and their annotated locations for NP_598736.4

      Status: VALIDATED

      Source sequence(s)
      AC123882, AK158807, AW543112, BG695625, CA319321, CF747879, CN536706, DV647354
      Consensus CDS
      CCDS35633.1
      UniProtKB/Swiss-Prot
      G5E870, Q3TY88, Q3UYT5, Q8BM59, Q8K051
      UniProtKB/TrEMBL
      A0A087WNZ7
      Related
      ENSMUSP00000027421.7, ENSMUST00000027421.13
      Conserved Domains (3) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1623 → 2023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769 → 830
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      84698910..84818285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238658.4 → XP_011236960.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236960.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1672 → 2072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814 → 876
      WWE; WWE domain

    2. XM_011238673.4 → XP_011236975.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1627 → 2027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767 → 832
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    3. XM_036160961.1 → XP_036016854.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:461 → 686
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1644 → 2044
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:786 → 848
      WWE; WWE domain

    4. XM_011238669.4 → XP_011236971.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

      See identical proteins and their annotated locations for XP_011236971.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1630 → 2030
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:770 → 835
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    5. XM_011238655.4 → XP_011236957.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236957.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1672 → 2072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814 → 876
      WWE; WWE domain

    6. XM_030249180.2 → XP_030105040.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1627 → 2027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767 → 832
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    7. XM_030249310.2 → XP_030105170.1  E3 ubiquitin-protein ligase TRIP12 isoform X30

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:418 → 643
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1598 → 1998
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:738 → 803
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    8. XM_030249285.2 → XP_030105145.1  E3 ubiquitin-protein ligase TRIP12 isoform X29

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:418 → 643
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1601 → 2001
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:741 → 806
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    9. XM_030249325.2 → XP_030105185.1  E3 ubiquitin-protein ligase TRIP12 isoform X33

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1591 → 1991
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767 → 804
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    10. XM_006496429.3 → XP_006496492.1  E3 ubiquitin-protein ligase TRIP12 isoform X31

      UniProtKB/TrEMBL
      A0A087WNZ7
      Related
      ENSMUSP00000139563.2, ENSMUST00000186648.7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1596 → 1996
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767 → 804
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    11. XM_006496427.4 → XP_006496490.1  E3 ubiquitin-protein ligase TRIP12 isoform X25

      See identical proteins and their annotated locations for XP_006496490.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1626 → 2026
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767 → 831
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    12. XM_030249168.2 → XP_030105028.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1627 → 2027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767 → 832
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    13. XM_011238668.4 → XP_011236970.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

      See identical proteins and their annotated locations for XP_011236970.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1630 → 2030
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:770 → 835
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    14. XM_036160829.1 → XP_036016722.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1672 → 2072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814 → 876
      WWE; WWE domain

    15. XM_006496416.5 → XP_006496479.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:811 → 872
      WWE; WWE domain

    16. XM_030249247.2 → XP_030105107.1  E3 ubiquitin-protein ligase TRIP12 isoform X27

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1618 → 2018
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769 → 830
      WWE; WWE domain

    17. XM_036161342.1 → XP_036017235.1  E3 ubiquitin-protein ligase TRIP12 isoform X32

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:418 → 643
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1594 → 1994
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:740 → 801
      WWE; WWE domain

    18. XM_030248998.2 → XP_030104858.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1641 → 2041
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809 → 846
      WWE; WWE domain

    19. XM_006496414.5 → XP_006496477.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1668 → 2068
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809 → 873
      WWE; WWE domain

    20. XM_030248922.2 → XP_030104782.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1661 → 2061
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809 → 874
      WWE; WWE domain

    21. XM_030248895.2 → XP_030104755.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1666 → 2066
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809 → 874
      WWE; WWE domain

    22. XM_006496409.5 → XP_006496472.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1669 → 2069
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809 → 874
      WWE; WWE domain

    23. XM_011238666.4 → XP_011236968.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1644 → 2044
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812 → 849
      WWE; WWE domain

    24. XM_036160909.1 → XP_036016802.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1663 → 2063
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814 → 875
      WWE; WWE domain

    25. XM_036160880.1 → XP_036016773.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1668 → 2068
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814 → 875
      WWE; WWE domain

    26. XM_011238661.4 → XP_011236963.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1671 → 2071
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812 → 876
      WWE; WWE domain

    27. XM_011238664.4 → XP_011236966.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1664 → 2064
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812 → 877
      WWE; WWE domain

    28. XM_011238663.4 → XP_011236965.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1667 → 2067
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812 → 877
      WWE; WWE domain

    29. XM_011238662.4 → XP_011236964.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1669 → 2069
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812 → 877
      WWE; WWE domain

    30. XM_011238654.4 → XP_011236956.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236956.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1672 → 2072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814 → 876
      WWE; WWE domain

    31. XM_006496422.5 → XP_006496485.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1638 → 2038
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809 → 846
      WWE; WWE domain

    32. XM_030248942.2 → XP_030104802.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1660 → 2060
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809 → 873
      WWE; WWE domain

    33. XM_030249012.2 → XP_030104872.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1639 → 2039
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809 → 847
      WWE; WWE domain

    34. XM_036161267.1 → XP_036017160.1  E3 ubiquitin-protein ligase TRIP12 isoform X26

      UniProtKB/Swiss-Prot
      G5E870, Q3TY88, Q3UYT5, Q8BM59, Q8K051
      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1623 → 2023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769 → 830
      WWE; WWE domain

    35. XM_030249259.2 → XP_030105119.1  E3 ubiquitin-protein ligase TRIP12 isoform X28

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:432 → 657
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1611 → 2011
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:752 → 816
      WWE; WWE domain

    36. XM_030249060.2 → XP_030104920.1  E3 ubiquitin-protein ligase TRIP12 isoform X22

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:460 → 685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1631 → 2031
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:780 → 844
      WWE; WWE domain

    37. XM_036161116.1 → XP_036017009.1  E3 ubiquitin-protein ligase TRIP12 isoform X21

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:460 → 685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1636 → 2036
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:782 → 843
      WWE; WWE domain

    38. XM_011238667.4 → XP_011236969.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:460 → 685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1643 → 2043
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:785 → 847
      WWE; WWE domain

    39. XM_017316673.3 → XP_017172162.1  E3 ubiquitin-protein ligase TRIP12 isoform X20

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:461 → 686
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1637 → 2037
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:781 → 845
      WWE; WWE domain

    40. XM_017316627.3 → XP_017172116.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:461 → 686
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1644 → 2044
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:786 → 848
      WWE; WWE domain

    41. XM_011238659.3 → XP_011236961.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236961.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1672 → 2072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814 → 876
      WWE; WWE domain

    42. XM_036160977.1 → XP_036016870.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:461 → 686
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1644 → 2044
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:786 → 848
      WWE; WWE domain

    43. XM_036161006.1 → XP_036016899.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:460 → 685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1643 → 2043
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:785 → 847
      WWE; WWE domain

    44. XM_011238657.4 → XP_011236959.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236959.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1672 → 2072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814 → 876
      WWE; WWE domain

    45. XM_011238670.4 → XP_011236972.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

      See identical proteins and their annotated locations for XP_011236972.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1630 → 2030
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:770 → 835
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    46. XM_030249195.2 → XP_030105055.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1627 → 2027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767 → 832
      WWE; WWE domain
      pfam07263
      Location:12 → 165
      DMP1; Dentin matrix protein 1 (DMP1)

    47. XM_036161252.1 → XP_036017145.1  E3 ubiquitin-protein ligase TRIP12 isoform X26

      UniProtKB/Swiss-Prot
      G5E870, Q3TY88, Q3UYT5, Q8BM59, Q8K051
      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1623 → 2023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769 → 830
      WWE; WWE domain

    48. XM_036160905.1 → XP_036016798.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:811 → 872
      WWE; WWE domain

    49. XM_036161289.1 → XP_036017182.1  E3 ubiquitin-protein ligase TRIP12 isoform X27

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1618 → 2018
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769 → 830
      WWE; WWE domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5E870.1 GenPept UniProtKB/Swiss-Prot:G5E870

    Gene LinkOut

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