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    Stac2 SH3 and cysteine rich domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 217154, updated on 17-Dec-2024

    Summary

    Official Symbol
    Stac2provided by MGI
    Official Full Name
    SH3 and cysteine rich domain 2provided by MGI
    Primary source
    MGI:MGI:2144518
    See related
    Ensembl:ENSMUSG00000017400 AllianceGenome:MGI:2144518
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    24b2; 24b2/STAC2
    Summary
    Predicted to enable metal ion binding activity. Involved in positive regulation of protein localization to plasma membrane and positive regulation of voltage-gated calcium channel activity. Located in cytoplasmic side of plasma membrane. Is expressed in metanephros. Orthologous to human STAC2 (SH3 and cysteine rich domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 12.8), cortex adult (RPKM 11.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Stac2 in Genome Data Viewer
    Location:
    11 D; 11 61.58 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97927449..97944288, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98036623..98053462, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10711 Neighboring gene STARR-positive B cell enhancer ABC_E5274 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97861691-97862052 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97864016-97864125 Neighboring gene STARR-positive B cell enhancer ABC_E11491 Neighboring gene ADP-ribosylation factor-like 5C Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene ribosomal protein L19 Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene ribosomal protein S6 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    General gene information

    Clone Names

    • MGC38869

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding  
    enables molecular_function  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane PubMed 
    located_in cytosol  
    located_in sarcolemma  

    General protein information

    Preferred Names
    SH3 and cysteine-rich domain-containing protein 2
    Names
    SRC homology 3 and cysteine-rich domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146028.4NP_666140.1  SH3 and cysteine-rich domain-containing protein 2

      See identical proteins and their annotated locations for NP_666140.1

      Status: PROVISIONAL

      Source sequence(s)
      AL591209
      Consensus CDS
      CCDS25338.1
      UniProtKB/Swiss-Prot
      Q8BV93, Q8K2U4, Q8R1B0
      Related
      ENSMUSP00000017544.3, ENSMUST00000017544.9
      Conserved Domains (4) summary
      cd11985
      Location:293345
      SH3_Stac2_C; C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
      cd00029
      Location:111161
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam16664
      Location:167292
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:352403
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97927449..97944288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245869.2XP_030101729.1  SH3 and cysteine-rich domain-containing protein 2 isoform X1

      Conserved Domains (3) summary
      cd11985
      Location:106158
      SH3_Stac2_C; C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
      pfam16664
      Location:3105
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:165216
      SH3; Src Homology 3 domain superfamily
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